1msw

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{{Seed}}
 
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[[Image:1msw.png|left|200px]]
 
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==Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase==
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The line below this paragraph, containing "STRUCTURE_1msw", creates the "Structure Box" on the page.
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<StructureSection load='1msw' size='340' side='right'caption='[[1msw]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1msw]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_phage_T7 Escherichia phage T7]. The April 2003 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''RNA Polymerase'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2003_4 10.2210/rcsb_pdb/mom_2003_4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MSW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1msw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1msw OCA], [https://pdbe.org/1msw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1msw RCSB], [https://www.ebi.ac.uk/pdbsum/1msw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1msw ProSAT]</span></td></tr>
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{{STRUCTURE_1msw| PDB=1msw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RPOL_BPT7 RPOL_BPT7] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Responsible for the transcription of the late genes of T7. It is rifampicin-resistant. It recognizes a specific promoter sequence, unwinds the double-stranded RNA to expose the coding strand for templating, initiates transcription preferentially with a purine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1msw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1msw ConSurf].
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<div style="clear:both"></div>
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===Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase===
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12242451}}, adds the Publication Abstract to the page
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[[Category: Escherichia phage T7]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12242451 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: RCSB PDB Molecule of the Month]]
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{{ABSTRACT_PUBMED_12242451}}
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==About this Structure==
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1MSW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t7 Enterobacteria phage t7]. Additional information on 1MSW is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb40_1.html RNA Polymerase] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSW OCA].
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==Reference==
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Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase., Yin YW, Steitz TA, Science. 2002 Nov 15;298(5597):1387-95. Epub 2002 Sep 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12242451 12242451]
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[[Category: DNA-directed RNA polymerase]]
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[[Category: Enterobacteria phage t7]]
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[[Category: RNA Polymerase]]
[[Category: RNA Polymerase]]
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[[Category: Single protein]]
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[[Category: Steitz TA]]
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[[Category: Steitz, T A.]]
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[[Category: Yin YW]]
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[[Category: Yin, Y W.]]
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[[Category: T7rnap elongation complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:54:51 2008''
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Current revision

Structural basis for the transition from initiation to elongation transcription in T7 RNA polymerase

PDB ID 1msw

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