1d2n

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{{Seed}}
 
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[[Image:1d2n.png|left|200px]]
 
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==D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN==
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The line below this paragraph, containing "STRUCTURE_1d2n", creates the "Structure Box" on the page.
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<StructureSection load='1d2n' size='340' side='right'caption='[[1d2n]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1d2n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. The August 2006 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''AAA+ Proteases'' by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2006_8 10.2210/rcsb_pdb/mom_2006_8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1D2N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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{{STRUCTURE_1d2n| PDB=1d2n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1d2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d2n OCA], [https://pdbe.org/1d2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1d2n RCSB], [https://www.ebi.ac.uk/pdbsum/1d2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1d2n ProSAT]</span></td></tr>
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</table>
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===D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN===
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== Function ==
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[https://www.uniprot.org/uniprot/NSF_CRIGR NSF_CRIGR] Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seem to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_9727495}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 9727495 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/d2/1d2n_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_9727495}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1D2N is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Cricetulus_griseus Cricetulus griseus]. Additional information on 1D2N is available in a page on [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb80_1.html AAA Proteases] at the RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1D2N OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1d2n ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein., Lenzen CU, Steinmann D, Whiteheart SW, Weis WI, Cell. 1998 Aug 21;94(4):525-36. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9727495 9727495]
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</StructureSection>
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[[Category: AAA Proteases]]
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[[Category: AAA+ Proteases]]
[[Category: Cricetulus griseus]]
[[Category: Cricetulus griseus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Lenzen, C U.]]
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[[Category: RCSB PDB Molecule of the Month]]
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[[Category: Steinmann, D.]]
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[[Category: Lenzen CU]]
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[[Category: Weis, W I.]]
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[[Category: Steinmann D]]
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[[Category: Whiteheart, S W.]]
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[[Category: Weis WI]]
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[[Category: Atpase]]
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[[Category: Whiteheart SW]]
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[[Category: Hexamerization domain]]
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[[Category: Transport]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 10:57:40 2008''
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Current revision

D2 DOMAIN OF N-ETHYLMALEIMIDE-SENSITIVE FUSION PROTEIN

PDB ID 1d2n

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