1jg5

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(New page: 200px<br /><applet load="1jg5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jg5, resolution 2.6&Aring;" /> '''CRYSTAL STRUCTURE OF ...)
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[[Image:1jg5.jpg|left|200px]]<br /><applet load="1jg5" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jg5, resolution 2.6&Aring;" />
 
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'''CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP==
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Tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic, amino acids regulates its own synthesis in mammals through feedback, inhibition of GTP cyclohydrolase I. This mechanism is mediated by a, regulatory subunit called GTP cyclohydrolase I feedback regulatory protein, (GFRP). The 2.6 A resolution crystal structure of rat GFRP shows that the, protein forms a pentamer. This indicates a model for the interaction of, mammalian GTP cyclohydrolase I with its regulator, GFRP. Kinetic, investigations of human GTP cyclohydrolase I in complex with rat and human, GFRP showed similar regulatory effects of both GFRP proteins.
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<StructureSection load='1jg5' size='340' side='right'caption='[[1jg5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jg5]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JG5 FirstGlance]. <br>
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1JG5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] with K as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JG5 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jg5 OCA], [https://pdbe.org/1jg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jg5 RCSB], [https://www.ebi.ac.uk/pdbsum/1jg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jg5 ProSAT]</span></td></tr>
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Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP., Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, Ploom T, Bacher A, Huber R, Lemm T, J Mol Biol. 2001 Oct 5;312(5):1051-7. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11580249 11580249]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GFRP_RAT GFRP_RAT] Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jg5_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jg5 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Auerbach G]]
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[[Category: Auerbach, G.]]
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[[Category: Bacher A]]
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[[Category: Bacher, A.]]
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[[Category: Bader G]]
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[[Category: Bader, G.]]
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[[Category: Fischer M]]
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[[Category: Fischer, M.]]
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[[Category: Gutlich M]]
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[[Category: Gutlich, M.]]
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[[Category: Herrmann A]]
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[[Category: Herrmann, A.]]
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[[Category: Huber R]]
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[[Category: Huber, R.]]
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[[Category: Lemm T]]
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[[Category: Lemm, T.]]
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[[Category: Ploom T]]
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[[Category: Ploom, T.]]
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[[Category: Schiffmann S]]
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[[Category: Schiffmann, S.]]
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[[Category: K]]
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[[Category: alpha/beta structure]]
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[[Category: beta sheet]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:13:05 2007''
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Current revision

CRYSTAL STRUCTURE OF RAT GTP CYCLOHYDROLASE I FEEDBACK REGULATORY PROTEIN, GFRP

PDB ID 1jg5

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