1jgk
From Proteopedia
(Difference between revisions)
(New page: 200px<br /><applet load="1jgk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jgk" /> '''SOLUTION STRUCTURE OF CANDOXIN'''<br /> ==A...) |
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| - | [[Image:1jgk.gif|left|200px]]<br /><applet load="1jgk" size="450" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1jgk" /> | ||
| - | '''SOLUTION STRUCTURE OF CANDOXIN'''<br /> | ||
| - | == | + | ==SOLUTION STRUCTURE OF CANDOXIN== |
| - | + | <StructureSection load='1jgk' size='340' side='right'caption='[[1jgk]]' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[1jgk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bungarus_candidus Bungarus candidus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGK FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 19 models</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgk OCA], [https://pdbe.org/1jgk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgk RCSB], [https://www.ebi.ac.uk/pdbsum/1jgk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgk ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/3NO4_BUNCA 3NO4_BUNCA] Binds and inhibits muscular and neuronal nicotinic acetylcholine receptors (nAChR). Is a reversible antagonist of muscle nAChR (alpha-1-beta-1-delta-epsilon/CHRNA1-CHRNB1-CHRND-CHRNE) (IC(50)=10 nM) and a potent and poorly reversible antagonist of the neuronal alpha-7/CHRNA7 nAChR (IC(50)=50 nM). May exhibit differential affinities for the two binding sites on the muscle nAChR.<ref>PMID:11884390</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgk_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgk ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Bungarus candidus]] | [[Category: Bungarus candidus]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Chary | + | [[Category: Chary KVR]] |
| - | [[Category: Govil | + | [[Category: Govil G]] |
| - | [[Category: Kini | + | [[Category: Kini MR]] |
| - | [[Category: Venkitakrishnan | + | [[Category: Venkitakrishnan RP]] |
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Current revision
SOLUTION STRUCTURE OF CANDOXIN
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