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1jgs

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(New page: 200px<br /><applet load="1jgs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jgs, resolution 2.3&Aring;" /> '''Multiple Antibiotic R...)
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[[Image:1jgs.jpg|left|200px]]<br /><applet load="1jgs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jgs, resolution 2.3&Aring;" />
 
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'''Multiple Antibiotic Resistance Repressor, MarR'''<br />
 
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==Overview==
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==Multiple Antibiotic Resistance Repressor, MarR==
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MarR is a regulator of multiple antibiotic resistance in Escherichia coli., It is the prototypical member of the MarR family of regulatory proteins, found in bacteria and archaea that play important roles in the development, of antibiotic resistance, a global health problem. Here we describe the, crystal structure of the MarR protein, determined at a resolution of 2.3, A. This is the first reported crystal structure of a member of this, newly-described protein family. The structure shows MarR as a dimer with, each subunit containing a winged-helix DNA binding motif.
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<StructureSection load='1jgs' size='340' side='right'caption='[[1jgs]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jgs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JGS FirstGlance]. <br>
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1JGS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with SAL as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JGS OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAL:2-HYDROXYBENZOIC+ACID'>SAL</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jgs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jgs OCA], [https://pdbe.org/1jgs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jgs RCSB], [https://www.ebi.ac.uk/pdbsum/1jgs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jgs ProSAT]</span></td></tr>
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The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolution., Alekshun MN, Levy SB, Mealy TR, Seaton BA, Head JF, Nat Struct Biol. 2001 Aug;8(8):710-4. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11473263 11473263]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MARR_ECOLI MARR_ECOLI] Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes. Binds to the marO operator/promoter site.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jg/1jgs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jgs ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Alekshun, M.N.]]
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[[Category: Alekshun MN]]
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[[Category: Head, J.F.]]
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[[Category: Head JF]]
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[[Category: Levy, S.B.]]
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[[Category: Levy SB]]
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[[Category: Mealy, T.R.]]
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[[Category: Mealy TR]]
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[[Category: Seaton, B.A.]]
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[[Category: Seaton BA]]
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[[Category: SAL]]
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[[Category: antibiotic resistance]]
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[[Category: dna-binding]]
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[[Category: repressor]]
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[[Category: transcription regulation]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:14:27 2007''
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Current revision

Multiple Antibiotic Resistance Repressor, MarR

PDB ID 1jgs

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