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3c72

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{{Seed}}
 
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[[Image:3c72.jpg|left|200px]]
 
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==Engineered RabGGTase in complex with a peptidomimetic inhibitor==
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The line below this paragraph, containing "STRUCTURE_3c72", creates the "Structure Box" on the page.
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<StructureSection load='3c72' size='340' side='right'caption='[[3c72]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3c72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3C72 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CX1:N-[(BENZYLOXY)CARBONYL]-L-HISTIDYL-N-METHYL-L-PHENYLALANYL-L-TYROSINE'>CX1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3c72| PDB=3c72 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3c72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3c72 OCA], [https://pdbe.org/3c72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3c72 RCSB], [https://www.ebi.ac.uk/pdbsum/3c72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3c72 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PGTA_RAT PGTA_RAT] Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to both cysteines in Rab proteins with an -XXCC, -XCXC and -CCXX C-terminal, such as RAB1A, RAB3A and RAB5A respectively.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c7/3c72_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3c72 ConSurf].
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<div style="clear:both"></div>
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===Engineered RabGGTase in complex with a peptidomimetic inhibitor===
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==See Also==
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*[[Geranylgeranyl transferase 3D structures|Geranylgeranyl transferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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3C72 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3C72 OCA].
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[[Category: Large Structures]]
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==Reference==
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Development of selective RabGGTase inhibitors and crystal structure of a RabGGTase-inhibitor complex., Guo Z, Wu YW, Tan KT, Bon RS, Guiu-Rozas E, Delon C, Nguyen TU, Wetzel S, Arndt S, Goody RS, Blankenfeldt W, Alexandrov K, Waldmann H, Angew Chem Int Ed Engl. 2008;47(20):3747-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18399557 18399557]
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[[Category: Protein complex]]
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[[Category: Protein geranylgeranyltransferase type II]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Alexandrov, K.]]
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[[Category: Alexandrov K]]
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[[Category: Arndt, S.]]
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[[Category: Arndt S]]
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[[Category: Blankenfeldt, W.]]
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[[Category: Blankenfeldt W]]
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[[Category: Bon, R S.]]
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[[Category: Bon RS]]
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[[Category: Delon, C.]]
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[[Category: Delon C]]
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[[Category: Goody, R S.]]
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[[Category: Goody RS]]
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[[Category: Guiu-Rozas, E.]]
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[[Category: Guiu-Rozas E]]
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[[Category: Guo, Z.]]
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[[Category: Guo Z]]
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[[Category: Nguyen, U T.]]
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[[Category: Nguyen UT]]
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[[Category: Tan, K T.]]
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[[Category: Tan KT]]
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[[Category: Waldmann, H.]]
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[[Category: Waldmann H]]
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[[Category: Wetzel, S.]]
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[[Category: Wetzel S]]
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[[Category: Wu, Y W.]]
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[[Category: Wu YW]]
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[[Category: Metal-binding]]
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[[Category: Peptide inhibitor]]
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[[Category: Phosphoprotein]]
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[[Category: Prenyltransferase]]
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[[Category: Rab prenylation]]
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[[Category: Transferase]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:46:54 2008''
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Current revision

Engineered RabGGTase in complex with a peptidomimetic inhibitor

PDB ID 3c72

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