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3cpw

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{{Seed}}
 
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[[Image:3cpw.jpg|left|200px]]
 
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==The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI==
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The line below this paragraph, containing "STRUCTURE_3cpw", creates the "Structure Box" on the page.
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<StructureSection load='3cpw' size='340' side='right'caption='[[3cpw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3cpw]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3CPW FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SR:STRONTIUM+ION'>SR</scene>, <scene name='pdbligand=ZLD:N-{[(5S)-3-(3-FLUORO-4-MORPHOLIN-4-YLPHENYL)-2-OXO-1,3-OXAZOLIDIN-5-YL]METHYL}ACETAMIDE'>ZLD</scene></td></tr>
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{{STRUCTURE_3cpw| PDB=3cpw | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3cpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3cpw OCA], [https://pdbe.org/3cpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3cpw RCSB], [https://www.ebi.ac.uk/pdbsum/3cpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3cpw ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL3_HALMA RL3_HALMA] One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).[HAMAP-Rule:MF_01325_A]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cp/3cpw_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3cpw ConSurf].
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<div style="clear:both"></div>
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===The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI===
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==See Also==
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_18494460}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 18494460 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_18494460}}
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==About this Structure==
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3CPW is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Haloarcula_marismortui Haloarcula marismortui]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CPW OCA].
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==Reference==
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Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit., Ippolito JA, Kanyo ZF, Wang D, Franceschi FJ, Moore PB, Steitz TA, Duffy EM, J Med Chem. 2008 Jun 26;51(12):3353-6. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18494460 18494460]
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[[Category: Haloarcula marismortui]]
[[Category: Haloarcula marismortui]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Duffy, E M.]]
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[[Category: Duffy EM]]
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[[Category: Franceschi, F J.]]
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[[Category: Franceschi FJ]]
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[[Category: Ippolito, J A.]]
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[[Category: Ippolito JA]]
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[[Category: Kanyo, Z K.]]
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[[Category: Kanyo ZK]]
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[[Category: Moore, P B.]]
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[[Category: Moore PB]]
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[[Category: Steitz, T A.]]
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[[Category: Steitz TA]]
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[[Category: Wang, D.]]
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[[Category: Wang D]]
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[[Category: 50s ribosomal subunit]]
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[[Category: Acetylation]]
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[[Category: Antibiotic complex]]
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[[Category: Linezolid]]
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[[Category: Metal-binding]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Trna-binding]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 11:48:50 2008''
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Current revision

The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI

PDB ID 3cpw

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