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3do7

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(New page: '''Unreleased structure''' The entry 3do7 is ON HOLD Authors: Fusco, A., Huang, D.B., Miller, D., Vu, D., Ghosh, G. Description: X-ray structure of a NF-kB p52/RelB/DNA complex ''Page...)
Current revision (09:00, 30 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 3do7 is ON HOLD
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==X-ray structure of a NF-kB p52/RelB/DNA complex==
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<StructureSection load='3do7' size='340' side='right'caption='[[3do7]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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Authors: Fusco, A., Huang, D.B., Miller, D., Vu, D., Ghosh, G.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3do7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3DO7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3DO7 FirstGlance]. <br>
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Description: X-ray structure of a NF-kB p52/RelB/DNA complex
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3do7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3do7 OCA], [https://pdbe.org/3do7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3do7 RCSB], [https://www.ebi.ac.uk/pdbsum/3do7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3do7 ProSAT]</span></td></tr>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 12:15:46 2008''
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RELB_MOUSE RELB_MOUSE] NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias.<ref>PMID:22565310</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/do/3do7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3do7 ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculus]]
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[[Category: Fusco A]]
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[[Category: Ghosh G]]
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[[Category: Huang DB]]
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[[Category: Miller D]]
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[[Category: Vu D]]

Current revision

X-ray structure of a NF-kB p52/RelB/DNA complex

PDB ID 3do7

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