This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.

1jk9

From Proteopedia

(Difference between revisions)

Jump to: navigation, search

Current revision

Heterodimer between H48F-ySOD1 and yCCS

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1jk9"

@@ Line 1: / Line 1: @@
-[[Image:1jk9.jpg|left|200px]]<br /><applet load="1jk9" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1jk9, resolution 2.9&Aring;" />
-'''Heterodimer between H48F-ySOD1 and yCCS'''<br />
-==Overview==
+==Heterodimer between H48F-ySOD1 and yCCS==
-The copper chaperone for superoxide dismutase (CCS) activates the, eukaryotic antioxidant enzyme copper, zinc superoxide dismutase (SOD1)., The 2.9 A resolution structure of yeast SOD1 complexed with yeast CCS, (yCCS) reveals that SOD1 interacts with its metallochaperone to form a, complex comprising one monomer of each protein. The heterodimer interface, is remarkably similar to the SOD1 and yCCS homodimer interfaces. Striking, conformational rearrangements are observed in both the chaperone and, target enzyme upon complex formation, and the functionally essential, C-terminal domain of yCCS is well positioned to play a key role in the, metal ion transfer mechanism. This domain is linked to SOD1 by an, intermolecular disulfide bond that may facilitate or regulate copper, delivery.
+<StructureSection load='1jk9' size='340' side='right'caption='[[1jk9]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1jk9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JK9 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jk9 OCA], [https://pdbe.org/1jk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jk9 RCSB], [https://www.ebi.ac.uk/pdbsum/1jk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jk9 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SODC_YEAST SODC_YEAST] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jk/1jk9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jk9 ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-JK9 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] with ZN and SO4 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Superoxide_dismutase Superoxide dismutase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.15.1.1 1.15.1.1] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JK9 OCA].
+*[[Superoxide dismutase 3D structures|Superoxide dismutase 3D structures]]
+__TOC__
-==Reference==
+</StructureSection>
-Heterodimeric structure of superoxide dismutase in complex with its metallochaperone., Lamb AL, Torres AS, O'Halloran TV, Rosenzweig AC, Nat Struct Biol. 2001 Sep;8(9):751-5. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=11524675 11524675]
+[[Category: Large Structures]]
-[[Category: Protein complex]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Superoxide dismutase]]
+[[Category: Lamb AL]]
-[[Category: Halloran, T.V.O.]]
+[[Category: O'Halloran TV]]
-[[Category: Lamb, A.L.]]
+[[Category: Rosenzweig AC]]
-[[Category: Rosenzweig, A.C.]]
+[[Category: Torres AS]]
-[[Category: Torres, A.S.]]
-[[Category: SO4]]
-[[Category: ZN]]
-[[Category: amyotrophic lateral sclerosis]]
-[[Category: chaperone]]
-[[Category: copper]]
-[[Category: heterodimer]]
-[[Category: lou gehrig's disease]]
-[[Category: metallochaperone]]
-[[Category: protein-protein complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:20:30 2007''

1jk9

From Proteopedia

Current revision

Heterodimer between H48F-ySOD1 and yCCS

Structural highlights

Function

Evolutionary Conservation

See Also

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox