1qt2
From Proteopedia
(Difference between revisions)
(New page: '''Theoretical Model''' The entry 1QT2 is a Theoretical Model titled 'BUNDLE FORMING PILIN OF ENTEROPATHOGENIC E. COLI'. Category:Theoretical Model ''Page seeded by [http://oca.wei...) |
|||
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | {{Theoretical_model}} | |
| - | + | ==BUNDLE FORMING PILIN OF ENTEROPATHOGENIC E. COLI== | |
| + | <StructureSection load='1qt2' size='340' side='right'caption='[[1qt2]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QT2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qt2 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1qt2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qt2 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A complete three-dimensional model (RCSB001169; PDB code 1qqz ) for the Vibrio cholerae toxin coregulated pilus protein (TcpA), including residues 1-197, is presented. We have used the crystal structure of the Neisseria gonorrhoeae pilin (PilE), available biochemical data about TcpA, variations in the primary sequences of TcpA among various Vibrio cholerae strains and secondary structure prediction, hydrophilicity, surface probability and antigenicity plots for TcpA to build our model. In our TcpA model, the first 137 residues possess a structure similar to the PilE, but the remainder is different. Though the ladle shape is still preserved, TcpA possesses a larger ladle head or globular domain compared to PilE. Using this model, it has been possible to identify two kinds of conserved residues: (i) those forming the core of the TcpA monomer and (ii) those involved in the monomer-monomer interactions leading to fibre formation. Residues on the fibre exterior, important in the mediation of bacterium (pilus)-bacterium (pilus) and bacterium (pilus)-host interactions, show more variability in comparison to those of (i) and (ii). | ||
| - | + | Model of Vibrio cholerae toxin coregulated pilin capable of filament formation.,Chattopadhyaya R, Ghose AC Protein Eng. 2002 Apr;15(4):297-304. PMID:11983930<ref>PMID:11983930</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 1qt2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Chattopadhyaya, R]] | ||
| + | [[Category: Ghose, A C]] | ||
Current revision
 |
BUNDLE FORMING PILIN OF ENTEROPATHOGENIC E. COLI
| |||||||||||
