This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1zo6
From Proteopedia
(Difference between revisions)
(New page: '''Theoretical Model''' The entry 1ZO6 is a Theoretical Model titled 'NMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C-TERMINAL UBA DOMAIN OF hHR23A'. [[Category:Theoretical M...) |
|||
| (10 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | + | {{Theoretical_model}} | |
| - | + | ==NMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C- TERMINAL UBA DOMAIN OF HHR23A== | |
| + | <StructureSection load='1zo6' size='340' side='right'caption='[[1zo6]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZO6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zo6 FirstGlance], [https://www.ebi.ac.uk/pdbsum/1zo6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zo6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Although functional diversity in polyubiquitin chain signaling has been ascribed to the ability of differently linked chains to bind in a distinctive manner to effector proteins, structural models of such interactions have been lacking. Here, we use NMR to unveil the structural basis of selective recognition of Lys48-linked di- and tetraubiquitin chains by the UBA2 domain of hHR23A. Although the interaction of UBA2 with Lys48-linked diubiquitin involves the same hydrophobic surface on each ubiquitin unit as that utilized in monoubiquitin:UBA complexes, our results show how the "closed" conformation of Lys48-linked diubiquitin is crucial for high-affinity binding. Moreover, recognition of Lys48-linked diubiquitin involves a unique epitope on UBA, which allows the formation of a sandwich-like diubiqutin:UBA complex. Studies of the UBA-tetraubiquitin interaction suggest that this mode of UBA binding to diubiquitin is relevant for longer chains. | ||
| - | + | Structural determinants for selective recognition of a Lys48-linked polyubiquitin chain by a UBA domain.,Varadan R, Assfalg M, Raasi S, Pickart C, Fushman D Mol Cell. 2005 Jun 10;18(6):687-98. PMID:15949443<ref>PMID:15949443</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 1zo6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Assfalg, M]] | ||
| + | [[Category: Fushman, D]] | ||
| + | [[Category: Pickart, C]] | ||
| + | [[Category: Raasi, S]] | ||
| + | [[Category: Varadan, R]] | ||
Current revision
 |
NMR BASED MODEL OF LYS48-LINKED DI-UBIQUITIN COMPLEX WITH C- TERMINAL UBA DOMAIN OF HHR23A
| |||||||||||
