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262d
From Proteopedia
(Difference between revisions)
(New page: '''Theoretical Model''' The entry 262D is a Theoretical Model titled 'A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV-1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS'. ...) |
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| - | + | {{Theoretical_model}} | |
| - | + | ==A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS== | |
| + | <StructureSection load='262d' size='340' side='right'caption='[[262d]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=262D FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=262d FirstGlance], [https://www.ebi.ac.uk/pdbsum/262d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=262d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Coordinated variations in the sequence of the Rev-binding element of HIV-1, identified by in vitro genetic selections, have been used as distance and conformational constraints for molecular modelling. Three-dimensional models of the wild-type Rev-binding element and several, evolved RNA ligands (aptamers) have been constructed. These models demonstrate that non-Watson-Crick pairings open the major groove allowing access of an alpha-helical peptide from Rev, and explain why some selected RNA sequences can bind Rev more tightly than others. | ||
| - | + | A three-dimensional model of the Rev-binding element of HIV-1 derived from analyses of aptamers.,Leclerc F, Cedergren R, Ellington AD Nat Struct Biol. 1994 May;1(5):293-300. PMID:7664035<ref>PMID:7664035</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 262d" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Cedergren, R J]] | ||
| + | [[Category: Ellington, A D]] | ||
| + | [[Category: Leclerc, F]] | ||
Current revision
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A THREE-DIMENSIONAL MODEL OF THE REV BINDING ELEMENT OF HIV- 1 DERIVED FROM ANALYSES OF IN VITRO SELECTED VARIANTS
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