2hcq
From Proteopedia
(Difference between revisions)
(New page: '''Theoretical Model''' The entry 2HCQ is a Theoretical Model titled 'THREE-DIMENSIONAL MODEL OF APHID ACETYLCHOLINESTERASE'. Category:Theoretical Model ''Page seeded by [http://oc...) |
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| - | + | {{Theoretical_model}} | |
| - | + | ==THREE-DIMENSIONAL MODEL OF APHID ACETYLCHOLINESTERASE== | |
| + | <StructureSection load='2hcq' size='340' side='right'caption='[[2hcq]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HCQ FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hcq FirstGlance], [https://www.ebi.ac.uk/pdbsum/2hcq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hcq ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Current anticholinesterase pesticides developed during World War II are toxic to mammals because they target a catalytic serine residue of acetylcholinesterases (AChEs) in insects and in mammals. A sequence analysis of AChEs from 68 species and three-dimensional models of the greenbug and English grain aphid AChEs reported herein reveal that a cysteine residue is present at the active sites of greenbug and aphid AChEs but absent at those of mammalian AChEs. This discovery enables the design of novel and safe pesticides that target the cysteine residue rather than the ubiquitous serine residue. | ||
| - | + | Species marker for developing novel and safe pesticides.,Pang YP Bioorg Med Chem Lett. 2007 Jan 1;17(1):197-9. Epub 2006 Oct 12. PMID:17046256<ref>PMID:17046256</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 2hcq" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Pang, Y.-P]] | ||
Current revision
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THREE-DIMENSIONAL MODEL OF APHID ACETYLCHOLINESTERASE
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