2hif
From Proteopedia
(Difference between revisions)
(New page: '''Theoretical Model''' The entry 2HIF is a Theoretical Model titled 'A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2'. Category:Theoretical Model ''Page seeded by [http://oca.weizman...) |
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| - | + | {{Theoretical_model}} | |
| - | + | ==A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2== | |
| + | <StructureSection load='2hif' size='340' side='right'caption='[[2hif]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HIF FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hif FirstGlance], [https://www.ebi.ac.uk/pdbsum/2hif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hif ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | An atomic coordinate five alpha-helix three-dimensional model is presented for human interferon alpha-2 (HuIFN alpha 2). The HuIFN alpha 2 structure was constructed from murine interferon beta (MuIFN beta) by homology modeling using the STEREO and IMPACT programs. The HuIFN alpha 2 model is consistent with its known biochemical and biophysical properties including epitope mapping. Lysine residues predicted to be buried in the model were primarily unreactive with succinimidyl-7-amino-4-methylcoumarin-3-acetic acid (AMCA-NHS), a lysine modification agent, as shown by mass spectrometric analysis of tryptic digests. N-terminal sequence analysis of polypeptides generated by limited digestion of HuIFN alpha 2 with endoproteinase Lys-C demonstrated rapid cleavage at K31, which is consistent with the presence of this residue in a loop in the proposed HuIFN alpha 2 model. Based on this model structure potential receptor binding sites are identified. | ||
| - | + | A homology model of human interferon alpha-2.,Murgolo NJ, Windsor WT, Hruza A, Reichert P, Tsarbopoulos A, Baldwin S, Huang E, Pramanik B, Ealick S, Trotta PP Proteins. 1993 Sep;17(1):62-74. PMID:8234245<ref>PMID:8234245</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | + | </div> | |
| + | <div class="pdbe-citations 2hif" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Theoretical Model]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Ealick, S]] | ||
| + | [[Category: Hruza, A]] | ||
| + | [[Category: Murgolo, N J]] | ||
| + | [[Category: Reichert, P]] | ||
| + | [[Category: Trotta, P P]] | ||
| + | [[Category: Windsor, W T]] | ||
Current revision
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A HOMOLOGY MODEL OF HUMAN INTERFERON ALPHA-2
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