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2fj7

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{{Seed}}
 
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[[Image:2fj7.png|left|200px]]
 
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==Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element==
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The line below this paragraph, containing "STRUCTURE_2fj7", creates the "Structure Box" on the page.
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<StructureSection load='2fj7' size='340' side='right'caption='[[2fj7]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fj7]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJ7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FJ7 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fj7 OCA], [https://pdbe.org/2fj7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fj7 RCSB], [https://www.ebi.ac.uk/pdbsum/2fj7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fj7 ProSAT]</span></td></tr>
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{{STRUCTURE_2fj7| PDB=2fj7 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/H32_XENLA H32_XENLA] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fj/2fj7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fj7 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element===
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==See Also==
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*[[Histone 3D structures|Histone 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16860337}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 16860337 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16860337}}
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==About this Structure==
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2FJ7 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FJ7 OCA].
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==Reference==
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Nucleosome core particles containing a poly(dA.dT) sequence element exhibit a locally distorted DNA structure., Bao Y, White CL, Luger K, J Mol Biol. 2006 Aug 25;361(4):617-24. Epub 2006 Jul 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16860337 16860337]
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[[Category: Protein complex]]
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[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Bao, Y.]]
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[[Category: Bao Y]]
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[[Category: Luger, K.]]
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[[Category: Luger K]]
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[[Category: White, C L.]]
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[[Category: White CL]]
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[[Category: Narrow minor groove]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 23 13:38:40 2008''
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Current revision

Crystal structure of Nucleosome Core Particle Containing a Poly (dA.dT) Sequence Element

PDB ID 2fj7

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