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2fam

From Proteopedia

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{{Seed}}
 
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[[Image:2fam.png|left|200px]]
 
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==X-RAY CRYSTAL STRUCTURE OF FERRIC APLYSIA LIMACINA MYOGLOBIN IN DIFFERENT LIGANDED STATES==
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The line below this paragraph, containing "STRUCTURE_2fam", creates the "Structure Box" on the page.
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<StructureSection load='2fam' size='340' side='right'caption='[[2fam]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fam]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplli Aplli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FAM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FAM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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-->
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene></td></tr>
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{{STRUCTURE_2fam| PDB=2fam | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fam FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fam OCA], [https://pdbe.org/2fam PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fam RCSB], [https://www.ebi.ac.uk/pdbsum/2fam PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fam ProSAT]</span></td></tr>
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</table>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fa/2fam_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fam ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The X-ray crystal structure of the ligand-free ferric form of Aplysia limacina myoglobin (pH 6.0) has been refined at 1.7 A resolution (R = 15.1%), and its cyanide, thiocyanate and imidazole derivatives studied by difference Fourier techniques at atomic resolution. The crystallographic R-factors of the three different derivatives reported are 16.1%, 16.1% and 15.6% at 1.8 A, 2.0 A and 2.0 A resolution, respectively. The present results have been analyzed in parallel with previous crystallographic studies on the molecular structures of the fluoride and azide derivatives of ferric Aplysia limacina myoglobin. Ligand binding to the distal site of the heme pocket results in different networks of hydrogen bonds involving to various degrees the bound ligand, residue Arg(66)E10, the heme propionate III, ordered water molecules and/or protein backbone atoms from the CD region. In particular, Arg(66)E10 stabilizes the bound ligand and compensates for the absence of the hydrogen bond donor residue HisE7, commonly present in oxygen-carrying globins.
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===X-RAY CRYSTAL STRUCTURE OF FERRIC APLYSIA LIMACINA MYOGLOBIN IN DIFFERENT LIGANDED STATES===
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X-ray crystal structure of ferric Aplysia limacina myoglobin in different liganded states.,Conti E, Moser C, Rizzi M, Mattevi A, Lionetti C, Coda A, Ascenzi P, Brunori M, Bolognesi M J Mol Biol. 1993 Oct 5;233(3):498-508. PMID:8411158<ref>PMID:8411158</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2fam" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_8411158}}, adds the Publication Abstract to the page
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*[[Myoglobin 3D structures|Myoglobin 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8411158 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8411158}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Aplli]]
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2FAM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Aplysia_limacina Aplysia limacina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FAM OCA].
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[[Category: Large Structures]]
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[[Category: Ascenzi, P]]
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==Reference==
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[[Category: Bolognesi, M]]
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X-ray crystal structure of ferric Aplysia limacina myoglobin in different liganded states., Conti E, Moser C, Rizzi M, Mattevi A, Lionetti C, Coda A, Ascenzi P, Brunori M, Bolognesi M, J Mol Biol. 1993 Oct 5;233(3):498-508. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8411158 8411158]
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[[Category: Brunori, M]]
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[[Category: Aplysia limacina]]
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[[Category: Coda, A]]
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[[Category: Single protein]]
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[[Category: Conti, E]]
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[[Category: Ascenzi, P.]]
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[[Category: Lionetti, C]]
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[[Category: Bolognesi, M.]]
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[[Category: Mattevi, A]]
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[[Category: Brunori, M.]]
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[[Category: Moser, C]]
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[[Category: Coda, A.]]
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[[Category: Rizzi, M]]
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[[Category: Conti, E.]]
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[[Category: Lionetti, C.]]
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[[Category: Mattevi, A.]]
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[[Category: Moser, C.]]
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[[Category: Rizzi, M.]]
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[[Category: Oxygen storage]]
[[Category: Oxygen storage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:18:28 2008''
 

Current revision

X-RAY CRYSTAL STRUCTURE OF FERRIC APLYSIA LIMACINA MYOGLOBIN IN DIFFERENT LIGANDED STATES

PDB ID 2fam

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