2gd3

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{{Seed}}
 
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[[Image:2gd3.png|left|200px]]
 
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==NMR structure of S14G-humanin in 30% TFE solution==
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The line below this paragraph, containing "STRUCTURE_2gd3", creates the "Structure Box" on the page.
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<StructureSection load='2gd3' size='340' side='right'caption='[[2gd3]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gd3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GD3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GD3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gd3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gd3 OCA], [https://pdbe.org/2gd3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gd3 RCSB], [https://www.ebi.ac.uk/pdbsum/2gd3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gd3 ProSAT]</span></td></tr>
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{{STRUCTURE_2gd3| PDB=2gd3 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HUNIN_HUMAN HUNIN_HUMAN] Plays a role as a neuroprotective factor. Protects against death induced by multiple different familial Alzheimer disease genes and beta amyloid proteins in Alzheimer disease. Suppresses apoptosis by binding to BAX and preventing the translocation of BAX from the cytosol to mitochondria. Binds to IGFBP3 and specifically blocks IGFBP3-induced cell death Induces chemotaxis of mononuclear phagocytes via FPR2. Reduces the aggregation and fibrillary formation by suppressing the effect of APP on mononuclear phagocytes and acts by competitively inhibiting the access of FPRL1 to APP.<ref>PMID:11371646</ref> <ref>PMID:14561895</ref> <ref>PMID:11717357</ref> <ref>PMID:12732850</ref> <ref>PMID:15153530</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The NMR solution study of Ser14Gly-humanin (S14G-HN), a 1000-fold more potent derivative of humanin (HN), is reported. HN is 24-residue peptide that selectively suppresses neuronal cell death caused by Alzheimer's disease (AD)-specific insults and offers hope for the development of a cure against AD. In aqueous solution the NMR data show that S14G-HN is a flexible peptide with turn-like structures in its conformational ensemble distributed over an extensive part of its sequence from Pro3 to Glu15. In the more lipophilic environment of 30% TFE, an alpha-helical structure spanning residues Phe6 to Thr13 is identified. Comparison of these findings to the NMR structure of the parent HN and to existing structure-function relationship literature data outlines the important for activity structural features for this class of neuroprotective peptides, and brings forth flexibility as an important characteristic that may facilitate interactions with functional counterparts of the neuroprotection pathway.
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===NMR structure of S14G-humanin in 30% TFE solution===
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Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease.,Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M Biochem Biophys Res Commun. 2006 Oct 20;349(2):634-42. Epub 2006 Aug 23. PMID:16945331<ref>PMID:16945331</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2gd3" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 16945331 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_16945331}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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2GD3 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GD3 OCA].
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[[Category: Large Structures]]
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[[Category: Benaki D]]
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==Reference==
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[[Category: Evangelou A]]
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Solution structure of Ser14Gly-humanin, a potent rescue factor against neuronal cell death in Alzheimer's disease., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2006 Oct 20;349(2):634-42. Epub 2006 Aug 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16945331 16945331]
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[[Category: Livaniou E]]
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[[Category: Mikros E]]
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Solution structure of humanin, a peptide against Alzheimer's disease-related neurotoxicity., Benaki D, Zikos C, Evangelou A, Livaniou E, Vlassi M, Mikros E, Pelecanou M, Biochem Biophys Res Commun. 2005 Apr 1;329(1):152-60. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15721287 15721287]
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[[Category: Pelecanou M]]
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[[Category: Vlassi M]]
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A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta., Hashimoto Y, Niikura T, Tajima H, Yasukawa T, Sudo H, Ito Y, Kita Y, Kawasumi M, Kouyama K, Doyu M, Sobue G, Koide T, Tsuji S, Lang J, Kurokawa K, Nishimoto I, Proc Natl Acad Sci U S A. 2001 May 22;98(11):6336-41. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11371646 11371646]
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[[Category: Zikos C]]
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[[Category: Single protein]]
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[[Category: Benaki, D.]]
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[[Category: Evangelou, A.]]
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[[Category: Livaniou, E.]]
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[[Category: Mikros, E.]]
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[[Category: Pelecanou, M.]]
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[[Category: Vlassi, M.]]
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[[Category: Zikos, C.]]
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[[Category: Alzheimer's disease]]
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[[Category: Cd]]
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[[Category: Humanin]]
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[[Category: Neuroprotection]]
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[[Category: Nmr]]
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[[Category: S14g-humanin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:19:16 2008''
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Current revision

NMR structure of S14G-humanin in 30% TFE solution

PDB ID 2gd3

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