1skm

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{{Seed}}
 
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[[Image:1skm.png|left|200px]]
 
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==HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site==
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The line below this paragraph, containing "STRUCTURE_1skm", creates the "Structure Box" on the page.
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<StructureSection load='1skm' size='340' side='right'caption='[[1skm]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1skm]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SKM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HCX:(SOUTH)+BICYCLO[3.1.0]HEXANE'>HCX</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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{{STRUCTURE_1skm| PDB=1skm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1skm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1skm OCA], [https://pdbe.org/1skm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1skm RCSB], [https://www.ebi.ac.uk/pdbsum/1skm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1skm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTH1_HAEPH MTH1_HAEPH] This methylase recognizes the double-stranded sequence GCGC, causes specific methylation on C-2 on both strands, and protects the DNA from cleavage by the HhaI endonuclease.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sk/1skm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1skm ConSurf].
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<div style="clear:both"></div>
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===HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site===
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==See Also==
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*[[DNA methyltransferase 3D structures|DNA methyltransferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_15273274}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15273274 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15273274}}
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==About this Structure==
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1SKM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Haemophilus_haemolyticus Haemophilus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SKM OCA].
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==Reference==
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Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase., Horton JR, Ratner G, Banavali NK, Huang N, Choi Y, Maier MA, Marquez VE, MacKerell AD Jr, Cheng X, Nucleic Acids Res. 2004 Jul 23;32(13):3877-86. Print 2004. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15273274 15273274]
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[[Category: Haemophilus haemolyticus]]
[[Category: Haemophilus haemolyticus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Banavali, N.]]
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[[Category: Banavali N]]
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[[Category: Cheng, X.]]
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[[Category: Cheng X]]
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[[Category: Horton, J R.]]
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[[Category: Horton JR]]
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[[Category: Huang, N.]]
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[[Category: Huang N]]
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[[Category: MacKerell, A D.]]
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[[Category: MacKerell AD]]
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[[Category: Marquez, V E.]]
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[[Category: Marquez VE]]
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[[Category: Ratner, G.]]
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[[Category: Ratner G]]
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[[Category: Protein-dna complex containing constrained abasic unnatural base]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:32:01 2008''
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Current revision

HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site

PDB ID 1skm

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