2o0k

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{{Seed}}
 
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[[Image:2o0k.png|left|200px]]
 
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==T4 gp17 ATPase domain mutant==
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The line below this paragraph, containing "STRUCTURE_2o0k", creates the "Structure Box" on the page.
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<StructureSection load='2o0k' size='340' side='right'caption='[[2o0k]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2o0k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O0K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2O0K FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2o0k OCA], [https://pdbe.org/2o0k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2o0k RCSB], [https://www.ebi.ac.uk/pdbsum/2o0k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2o0k ProSAT]</span></td></tr>
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{{STRUCTURE_2o0k| PDB=2o0k | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TERL_BPT4 TERL_BPT4] Component of the molecular motor that translocates genomic DNA in empty capsid during DNA packaging. Heterodimerizes with small terminase protein to be docked on capsid portal protein. The latter forms a ring in which genomic DNA in translocated into the capsid. May have or induce an endonuclease activity to cleave the genome concatemer after encapsidation (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o0/2o0k_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2o0k ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Packaging the viral genome into empty procapsids, an essential event in the life cycle of tailed bacteriophages and some eukaryotic viruses, is a process that shares features with chromosome assembly. Most viral procapsids possess a special vertex containing a dodecameric portal protein that is used for entry and exit of the viral genome. The portal and an ATPase are parts of the genome-packaging machine. The ATPase is required to provide energy for translocation and compaction of the negative charges on the genomic DNA. Here we report the atomic structure of the ATPase component in a phage DNA-packaging machine. The bacteriophage T4 ATPase has the greatest similarity to monomeric helicases, suggesting that the genome is translocated by an inchworm mechanism. The similarity of the packaging machines in the double-stranded DNA (dsDNA) bacteriophage T4 and dsRNA bacteriophage varphi12 is consistent with the evolution of many virions from a common ancestor.
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===T4 gp17 ATPase domain mutant===
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The structure of the ATPase that powers DNA packaging into bacteriophage T4 procapsids.,Sun S, Kondabagil K, Gentz PM, Rossmann MG, Rao VB Mol Cell. 2007 Mar 23;25(6):943-9. PMID:17386269<ref>PMID:17386269</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17386269}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2o0k" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17386269 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17386269}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Escherichia virus T4]]
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2O0K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O0K OCA].
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[[Category: Large Structures]]
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[[Category: Rossmann MG]]
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==Reference==
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[[Category: Sun S]]
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The structure of the ATPase that powers DNA packaging into bacteriophage T4 procapsids., Sun S, Kondabagil K, Gentz PM, Rossmann MG, Rao VB, Mol Cell. 2007 Mar 23;25(6):943-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17386269 17386269]
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[[Category: Enterobacteria phage t4]]
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[[Category: Single protein]]
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[[Category: Rossmann, M G.]]
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[[Category: Sun, S.]]
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[[Category: Hydrolase]]
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[[Category: Nucleotide-binding fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:37:44 2008''
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Current revision

T4 gp17 ATPase domain mutant

PDB ID 2o0k

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