1wo5

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{{Seed}}
 
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[[Image:1wo5.png|left|200px]]
 
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==Solution structure of Designed Functional Finger 2 (DFF2): Designed mutant based on non-native CHANCE domain==
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The line below this paragraph, containing "STRUCTURE_1wo5", creates the "Structure Box" on the page.
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<StructureSection load='1wo5' size='340' side='right'caption='[[1wo5]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1wo5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WO5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WO5 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1wo5| PDB=1wo5 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wo5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wo5 OCA], [https://pdbe.org/1wo5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wo5 RCSB], [https://www.ebi.ac.uk/pdbsum/1wo5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wo5 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[https://omim.org/entry/180849 180849]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zinc binding motifs have received much attention in the area of protein design. Here, we have tested the suitability of a recently discovered nonnative zinc binding structure as a protein design scaffold. A series of multiple alanine mutants was created to investigate the minimal requirements for folding, and solution structures of these mutants showed that the original fold was maintained, despite changes in approximately 50% of the sequence. We next attempted to transplant binding faces from chosen bimolecular interactions onto one of these mutants, and many of the resulting "chimeras" were shown to adopt a native-like fold. These results both highlight the robust nature of small zinc binding domains and underscore the complexity of designing functional proteins, even using such small, highly ordered scaffolds as templates.
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===Solution structure of Designed Functional Finger 2 (DFF2): Designed mutant based on non-native CHANCE domain===
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Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting.,Sharpe BK, Liew CK, Kwan AH, Wilce JA, Crossley M, Matthews JM, Mackay JP Structure. 2005 Feb;13(2):257-66. PMID:15698569<ref>PMID:15698569</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1wo5" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_15698569}}, adds the Publication Abstract to the page
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*[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 15698569 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15698569}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Homo sapiens]]
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1WO5 is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WO5 OCA].
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[[Category: Large Structures]]
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[[Category: Crossley M]]
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==Reference==
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[[Category: Liew CK]]
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Assessment of the robustness of a serendipitous zinc binding fold: mutagenesis and protein grafting., Sharpe BK, Liew CK, Kwan AH, Wilce JA, Crossley M, Matthews JM, Mackay JP, Structure. 2005 Feb;13(2):257-66. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15698569 15698569]
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[[Category: Mackay JP]]
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[[Category: Histone acetyltransferase]]
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[[Category: Matthews JM]]
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[[Category: Single protein]]
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[[Category: Sharpe BK]]
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[[Category: Crossley, M.]]
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[[Category: Wilce JA]]
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[[Category: Liew, C K.]]
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[[Category: Mackay, J P.]]
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[[Category: Matthews, J M.]]
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[[Category: Sharpe, B K.]]
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[[Category: Wilce, J A.]]
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[[Category: Protein design]]
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[[Category: Zinc finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:04:49 2008''
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Current revision

Solution structure of Designed Functional Finger 2 (DFF2): Designed mutant based on non-native CHANCE domain

PDB ID 1wo5

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