1r4w

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{{Seed}}
 
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[[Image:1r4w.png|left|200px]]
 
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==Crystal structure of Mitochondrial class kappa glutathione transferase==
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The line below this paragraph, containing "STRUCTURE_1r4w", creates the "Structure Box" on the page.
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<StructureSection load='1r4w' size='340' side='right'caption='[[1r4w]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r4w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R4W FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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{{STRUCTURE_1r4w| PDB=1r4w | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r4w OCA], [https://pdbe.org/1r4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r4w RCSB], [https://www.ebi.ac.uk/pdbsum/1r4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r4w ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTK1_RAT GSTK1_RAT] Might confer protection against genotoxic and cytotoxic electrophiles in the mitochondrial compartment.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r4/1r4w_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1r4w ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Mitochondrial class kappa glutathione transferase===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_14717589}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14717589 is the PubMed ID number.
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{{ABSTRACT_PUBMED_14717589}}
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==About this Structure==
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1R4W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R4W OCA].
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==Reference==
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Parallel evolutionary pathways for glutathione transferases: structure and mechanism of the mitochondrial class kappa enzyme rGSTK1-1., Ladner JE, Parsons JF, Rife CL, Gilliland GL, Armstrong RN, Biochemistry. 2004 Jan 20;43(2):352-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14717589 14717589]
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[[Category: Glutathione transferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Single protein]]
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[[Category: Armstrong RN]]
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[[Category: Armstrong, R N.]]
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[[Category: Gilliland GL]]
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[[Category: Gilliland, G L.]]
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[[Category: Ladner JE]]
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[[Category: Ladner, J E.]]
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[[Category: Parsons JF]]
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[[Category: Parsons, J F.]]
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[[Category: Rife CL]]
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[[Category: Rife, C L.]]
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[[Category: Glutathione transferase]]
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[[Category: Glutathione-s-transferase]]
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[[Category: Kappa gst]]
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[[Category: Rgstk1-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:05:12 2008''
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Current revision

Crystal structure of Mitochondrial class kappa glutathione transferase

PDB ID 1r4w

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