2j9a

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{{Seed}}
 
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[[Image:2j9a.png|left|200px]]
 
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==blLAP in Complex with Microginin FR1==
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The line below this paragraph, containing "STRUCTURE_2j9a", creates the "Structure Box" on the page.
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<StructureSection load='2j9a' size='340' side='right'caption='[[2j9a]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2j9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Microcystis_sp. Microcystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J9A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.73&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AHY:(2S,3R)-3-AMINO-2-HYDROXYDECANOIC+ACID'>AHY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2j9a| PDB=2j9a | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j9a OCA], [https://pdbe.org/2j9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j9a RCSB], [https://www.ebi.ac.uk/pdbsum/2j9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j9a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AMPL_BOVIN AMPL_BOVIN] Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j9/2j9a_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j9a ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins are linear peptides known to inhibit various exopeptidases. The crystal structure of microginin FR1 from Microcystis sp. bound to bovine lens leucine aminopeptidase was established at 1.73 Angstrom resolution. The observed binding structure could be beneficial for the design of potent aminopeptidase inhibitors.
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===BLLAP IN COMPLEX WITH MICROGININ FR1===
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Binding structure of the leucine aminopeptidase inhibitor microginin FR1.,Kraft M, Schleberger C, Weckesser J, Schulz GE FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:17157838<ref>PMID:17157838</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2j9a" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_17157838}}, adds the Publication Abstract to the page
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 17157838 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17157838}}
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__TOC__
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</StructureSection>
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==About this Structure==
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2J9A is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [http://en.wikipedia.org/wiki/Microcystis_sp. Microcystis sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J9A OCA].
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==Reference==
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Binding structure of the leucine aminopeptidase inhibitor microginin FR1., Kraft M, Schleberger C, Weckesser J, Schulz GE, FEBS Lett. 2006 Dec 22;580(30):6943-7. Epub 2006 Dec 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17157838 17157838]
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Microcystis sp.]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Microcystis sp]]
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[[Category: Kraft, M.]]
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[[Category: Kraft M]]
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[[Category: Schleberger, C.]]
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[[Category: Schleberger C]]
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[[Category: Schulz, G E.]]
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[[Category: Schulz GE]]
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[[Category: Weckesser, J.]]
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[[Category: Weckesser J]]
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[[Category: Acetylation]]
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[[Category: Aminopeptidase]]
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[[Category: Inhibitor complex hydrolase]]
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[[Category: Leucine aminopeptidase]]
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[[Category: Metal-binding]]
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[[Category: Microcystin]]
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[[Category: Microginin]]
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[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:24:05 2008''
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Current revision

blLAP in Complex with Microginin FR1

PDB ID 2j9a

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