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2jsq

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{{Seed}}
 
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[[Image:2jsq.png|left|200px]]
 
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==Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 15BrG, NMR, 10 Structures==
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The line below this paragraph, containing "STRUCTURE_2jsq", creates the "Structure Box" on the page.
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<StructureSection load='2jsq' size='340' side='right'caption='[[2jsq]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2jsq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JSQ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGM:8-BROMO-2-DEOXYGUANOSINE-5-MONOPHOSPHATE'>BGM</scene></td></tr>
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{{STRUCTURE_2jsq| PDB=2jsq | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jsq OCA], [https://pdbe.org/2jsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jsq RCSB], [https://www.ebi.ac.uk/pdbsum/2jsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jsq ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Intramolecular G-quadruplexes formed by human telomere sequences are attractive anticancer targets. Recently, four-repeat human telomere sequences have been shown to form two different intramolecular (3 + 1) G-quadruplexes in K(+) solution (Form 1 and Form 2). Here we report on the solution structures of both Form 1 and Form 2 adopted by natural human telomere sequences. Both structures contain the (3 + 1) G-tetrad core with one double-chain-reversal and two edgewise loops, but differ in the successive order of loop arrangements within the G-quadruplex scaffold. Our results provide the structural details at the two ends of the G-tetrad core in the context of natural sequences and information on different loop conformations. This structural information might be important for our understanding of telomere G-quadruplex structures and for anticancer drug design targeted to such scaffolds.
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===Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 15BrG, NMR, 10 Structures===
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Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution.,Phan AT, Kuryavyi V, Luu KN, Patel DJ Nucleic Acids Res. 2007;35(19):6517-25. Epub 2007 Sep 25. PMID:17895279<ref>PMID:17895279</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17895279}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2jsq" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17895279 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17895279}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2JSQ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JSQ OCA].
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[[Category: Kuryavyi VV]]
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[[Category: Luu KN]]
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==Reference==
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[[Category: Patel DJ]]
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Structure of two intramolecular G-quadruplexes formed by natural human telomere sequences in K+ solution., Phan AT, Kuryavyi V, Luu KN, Patel DJ, Nucleic Acids Res. 2007;35(19):6517-25. Epub 2007 Sep 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17895279 17895279]
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[[Category: Phan AT]]
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[[Category: Single protein]]
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[[Category: Kuryavyi, V V.]]
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[[Category: Luu, K N.]]
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[[Category: Patel, D J.]]
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[[Category: Phan, A T.]]
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[[Category: 10 structure]]
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[[Category: 15brg form 2]]
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[[Category: 3+1 strand folding]]
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[[Category: Dna]]
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[[Category: Double-chain reversal loop]]
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[[Category: Edgewise]]
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[[Category: G-tetrad]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:29:31 2008''
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Current revision

Monomeric Human Telomere DNA Tetraplex with 3+1 Strand Fold Topology, Two Edgewise Loops and Double-Chain Reversal Loop, Form 2 15BrG, NMR, 10 Structures

PDB ID 2jsq

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