2r5i

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{{Seed}}
 
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[[Image:2r5i.png|left|200px]]
 
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==Pentamer Structure of Major Capsid Protein L1 of Human Papilloma Virus type 18==
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The line below this paragraph, containing "STRUCTURE_2r5i", creates the "Structure Box" on the page.
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<StructureSection load='2r5i' size='340' side='right'caption='[[2r5i]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2r5i]] is a 15 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R5I FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r5i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r5i OCA], [https://pdbe.org/2r5i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r5i RCSB], [https://www.ebi.ac.uk/pdbsum/2r5i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r5i ProSAT]</span></td></tr>
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{{STRUCTURE_2r5i| PDB=2r5i | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/VL1_HPV18 VL1_HPV18] Forms an icosahedral capsid with a T=7 symmetry and a 50 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with L2 proteins. Binds to heparan sulfate proteoglycans on cell surface of basal layer keratinocytes to provide initial virion attachment. This binding mediates a conformational change in the virus capsid that facilitates efficient infection. The virion enters the host cell via endocytosis. During virus trafficking, L1 protein dissociates from the viral DNA and the genomic DNA is released to the host nucleus. The virion assembly takes place within the cell nucleus. Encapsulates the genomic DNA together with protein L2.[HAMAP-Rule:MF_04002]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r5/2r5i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r5i ConSurf].
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<div style="clear:both"></div>
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===Pentamer Structure of Major Capsid Protein L1 of Human Papilloma Virus type 18===
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==See Also==
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17804402}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17804402 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17804402}}
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==About this Structure==
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2R5I is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_papillomavirus_type_18 Human papillomavirus type 18]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R5I OCA].
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==Reference==
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Crystal structures of four types of human papillomavirus L1 capsid proteins: understanding the specificity of neutralizing monoclonal antibodies., Bishop B, Dasgupta J, Klein M, Garcea RL, Christensen ND, Zhao R, Chen XS, J Biol Chem. 2007 Oct 26;282(43):31803-11. Epub 2007 Sep 4. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17804402 17804402]
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[[Category: Human papillomavirus type 18]]
[[Category: Human papillomavirus type 18]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bishop, B.]]
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[[Category: Bishop B]]
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[[Category: Chen, X S.]]
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[[Category: Chen XS]]
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[[Category: Dasgupta, J.]]
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[[Category: Dasgupta J]]
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[[Category: Capsid]]
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[[Category: Capsid protein]]
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[[Category: Hpv18]]
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[[Category: Pentamer]]
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[[Category: Structure]]
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[[Category: Type specific epitope]]
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[[Category: Viral protein]]
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[[Category: Virion]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:32:06 2008''
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Current revision

Pentamer Structure of Major Capsid Protein L1 of Human Papilloma Virus type 18

PDB ID 2r5i

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