2jhn

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:37, 9 May 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2jhn.png|left|200px]]
 
-
<!--
+
==3-methyladenine dna-glycosylase from Archaeoglobus fulgidus==
-
The line below this paragraph, containing "STRUCTURE_2jhn", creates the "Structure Box" on the page.
+
<StructureSection load='2jhn' size='340' side='right'caption='[[2jhn]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2jhn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JHN FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=MBO:MERCURIBENZOIC+ACID'>MBO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_2jhn| PDB=2jhn | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jhn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jhn OCA], [https://pdbe.org/2jhn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jhn RCSB], [https://www.ebi.ac.uk/pdbsum/2jhn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jhn ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/O28163_ARCFU O28163_ARCFU]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jh/2jhn_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2jhn ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
N(1)-methyladenine (m(1)A) and N(3)-methylcytosine (m(3)C) are major toxic and mutagenic lesions induced by alkylation in single-stranded DNA. In bacteria and mammals, m(1)A and m(3)C were recently shown to be repaired by AlkB-mediated oxidative demethylation, a direct DNA damage reversal mechanism. No AlkB gene homologues have been identified in Archaea. We report that m(1)A and m(3)C are repaired by the AfAlkA base excision repair glycosylase of Archaeoglobus fulgidus, suggesting a different repair mechanism for these lesions in the third domain of life. In addition, AfAlkA was found to effect a robust excision of 1,N(6)-ethenoadenine. We present a high-resolution crystal structure of AfAlkA, which, together with the characterization of several site-directed mutants, forms a molecular rationalization for the newly discovered base excision activity.
-
===3-METHYLADENINE DNA-GLYCOSYLASE FROM ARCHAEOGLOBUS FULGIDUS===
+
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA.,Leiros I, Nabong MP, Grosvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knaevelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S EMBO J. 2007 Apr 18;26(8):2206-17. Epub 2007 Mar 29. PMID:17396151<ref>PMID:17396151</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2jhn" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_17396151}}, adds the Publication Abstract to the page
+
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 17396151 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_17396151}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2JHN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JHN OCA].
+
-
 
+
-
==Reference==
+
-
Structural basis for enzymatic excision of N1-methyladenine and N3-methylcytosine from DNA., Leiros I, Nabong MP, Grosvik K, Ringvoll J, Haugland GT, Uldal L, Reite K, Olsbu IK, Knaevelsrud I, Moe E, Andersen OA, Birkeland NK, Ruoff P, Klungland A, Bjelland S, EMBO J. 2007 Apr 18;26(8):2206-17. Epub 2007 Mar 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17396151 17396151]
+
[[Category: Archaeoglobus fulgidus]]
[[Category: Archaeoglobus fulgidus]]
-
[[Category: DNA-3-methyladenine glycosylase II]]
+
[[Category: Large Structures]]
-
[[Category: Single protein]]
+
[[Category: Andersen OA]]
-
[[Category: Andersen, O A.]]
+
[[Category: Birkeland NK]]
-
[[Category: Birkeland, N K.]]
+
[[Category: Bjelland S]]
-
[[Category: Bjelland, S.]]
+
[[Category: Grosvik K]]
-
[[Category: Grosvik, K.]]
+
[[Category: Haugland GT]]
-
[[Category: Haugland, G T.]]
+
[[Category: Klungland A]]
-
[[Category: Klungland, A.]]
+
[[Category: Knaevelsrud I]]
-
[[Category: Knaevelsrud, I.]]
+
[[Category: Leiros I]]
-
[[Category: Leiros, I.]]
+
[[Category: Moe E]]
-
[[Category: Moe, E.]]
+
[[Category: Nabong MP]]
-
[[Category: Nabong, M P.]]
+
[[Category: Olsbu IK]]
-
[[Category: Olsbu, I K.]]
+
[[Category: Reite K]]
-
[[Category: Reite, K.]]
+
[[Category: Ringvoll J]]
-
[[Category: Ringvoll, J.]]
+
[[Category: Ruoff P]]
-
[[Category: Ruoff, P.]]
+
[[Category: Uldal L]]
-
[[Category: Uldal, L.]]
+
-
[[Category: Alka]]
+
-
[[Category: Archaeoglobus fulgidus]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hyperthermophile]]
+
-
[[Category: N1-methyladenine]]
+
-
[[Category: N3-methylcytosine]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:38:51 2008''
+

Current revision

3-methyladenine dna-glycosylase from Archaeoglobus fulgidus

PDB ID 2jhn

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2jhn"
Personal tools