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1jx7

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(New page: 200px<br /><applet load="1jx7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jx7, resolution 2.80&Aring;" /> '''Crystal structure of...)
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[[Image:1jx7.gif|left|200px]]<br /><applet load="1jx7" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jx7, resolution 2.80&Aring;" />
 
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'''Crystal structure of ychN protein from E.coli'''<br />
 
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==Overview==
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==Crystal structure of ychN protein from E.coli==
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The crystal structure of a conserved hypothetical protein from Escherichia, coli has been determined using X-ray crystallography. The protein belongs, to the Cluster of Orthologous Group COG1553 (National Center for, Biotechnology Information database, NLM, NIH), for which there was no, structural information available until now. Structural homology search, with DALI algorism indicated that this protein has a new fold with no, obvious similarity to those of other proteins with known three-dimensional, structures. The protein quaternary structure consists of a dimer of, trimers, which makes a characteristic cylinder shape. There is a large, closed cavity with approximate dimensions of 16 A x 16 A x 20 A in the, center of the hexameric structure. Six putative active sites are, positioned along the equatorial surface of the hexamer. There are several, highly conserved residues including two possible functional cysteines in, the putative active site. The possible molecular function of the protein, is discussed.
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<StructureSection load='1jx7' size='340' side='right'caption='[[1jx7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jx7]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JX7 FirstGlance]. <br>
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1JX7 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JX7 OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jx7 OCA], [https://pdbe.org/1jx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jx7 RCSB], [https://www.ebi.ac.uk/pdbsum/1jx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jx7 ProSAT], [https://www.topsan.org/Proteins/BSGC/1jx7 TOPSAN]</span></td></tr>
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Crystal structure of a conserved hypothetical protein from Escherichia coli., Shin DH, Yokota H, Kim R, Kim SH, J Struct Funct Genomics. 2002;2(1):53-66. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12836674 12836674]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YCHN_ECOLI YCHN_ECOLI]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jx/1jx7_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jx7 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: BSGC, Berkeley.Structural.Genomics.Center.]]
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[[Category: Kim R]]
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[[Category: Kim, R.]]
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[[Category: Kim S-H]]
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[[Category: Kim, S.H.]]
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[[Category: Shin DH]]
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[[Category: Shin, D.H.]]
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[[Category: Yokota H]]
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[[Category: Yokota, H.]]
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[[Category: berkeley structural genomics center]]
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[[Category: bsgc structure funded by nih]]
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[[Category: hexamer]]
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[[Category: new fold]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:39:26 2007''
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Current revision

Crystal structure of ychN protein from E.coli

PDB ID 1jx7

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