3yas

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{{Seed}}
 
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[[Image:3yas.png|left|200px]]
 
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==HYDROXYNITRILE LYASE COMPLEXED WITH ACETONE==
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The line below this paragraph, containing "STRUCTURE_3yas", creates the "Structure Box" on the page.
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<StructureSection load='3yas' size='340' side='right'caption='[[3yas]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3yas]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hevea_brasiliensis Hevea brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3YAS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3YAS FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACN:ACETONE'>ACN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3yas| PDB=3yas | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3yas FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3yas OCA], [https://pdbe.org/3yas PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3yas RCSB], [https://www.ebi.ac.uk/pdbsum/3yas PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3yas ProSAT]</span></td></tr>
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</table>
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===HYDROXYNITRILE LYASE COMPLEXED WITH ACETONE===
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== Function ==
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[https://www.uniprot.org/uniprot/HNL_HEVBR HNL_HEVBR] Involved in cyanogenesis, the release of HCN from injured tissues. Decomposes a varieties of (R) or (S) cyanohydrins into HCN and the corresponding aldehydes and ketones. The natural substrate of this enzyme is (S)-acetone cyanohydrin.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_10548044}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 10548044 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ya/3yas_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_10548044}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3YAS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hevea_brasiliensis Hevea brasiliensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3YAS OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3yas ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Three-dimensional structures of enzyme-substrate complexes of the hydroxynitrile lyase from Hevea brasiliensis., Zuegg J, Gruber K, Gugganig M, Wagner UG, Kratky C, Protein Sci. 1999 Oct;8(10):1990-2000. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10548044 10548044]
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</StructureSection>
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Hydroxynitrile lyase from Hevea brasiliensis: molecular characterization and mechanism of enzyme catalysis., Hasslacher M, Kratky C, Griengl H, Schwab H, Kohlwein SD, Proteins. 1997 Mar;27(3):438-49. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9094745 9094745]
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Mechanism of cyanogenesis: the crystal structure of hydroxynitrile lyase from Hevea brasiliensis., Wagner UG, Hasslacher M, Griengl H, Schwab H, Kratky C, Structure. 1996 Jul 15;4(7):811-22. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8805565 8805565]
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Molecular cloning of the full-length cDNA of (S)-hydroxynitrile lyase from Hevea brasiliensis. Functional expression in Escherichia coli and Saccharomyces cerevisiae and identification of an active site residue., Hasslacher M, Schall M, Hayn M, Griengl H, Kohlwein SD, Schwab H, J Biol Chem. 1996 Mar 8;271(10):5884-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8621461 8621461]
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[[Category: Hevea brasiliensis]]
[[Category: Hevea brasiliensis]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Transfered to EC 4 1.2 37]]
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[[Category: Gugganig M]]
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[[Category: Gugganig, M.]]
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[[Category: Kratky C]]
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[[Category: Kratky, C.]]
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[[Category: Wagner UG]]
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[[Category: Wagner, U G.]]
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[[Category: Zuegg J]]
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[[Category: Zuegg, J.]]
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[[Category: Cyanogenesis]]
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[[Category: Cyanohydrin formation]]
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[[Category: Lyase]]
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[[Category: Oxynitrilase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:10:28 2008''
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Current revision

HYDROXYNITRILE LYASE COMPLEXED WITH ACETONE

PDB ID 3yas

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