2ptv

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{{Seed}}
 
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[[Image:2ptv.png|left|200px]]
 
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==Structure of NK cell receptor ligand CD48==
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The line below this paragraph, containing "STRUCTURE_2ptv", creates the "Structure Box" on the page.
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<StructureSection load='2ptv' size='340' side='right'caption='[[2ptv]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ptv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PTV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ptv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ptv OCA], [https://pdbe.org/2ptv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ptv RCSB], [https://www.ebi.ac.uk/pdbsum/2ptv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ptv ProSAT]</span></td></tr>
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{{STRUCTURE_2ptv| PDB=2ptv | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CD48_MOUSE CD48_MOUSE] Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pt/2ptv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ptv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Natural killer (NK) cells eliminate virally infected and tumor cells. Among the receptors regulating NK cell function is 2B4 (CD244), a member of the signaling lymphocyte-activation molecule (SLAM) family that binds CD48. 2B4 is the only heterophilic receptor of the SLAM family, whose other members, e.g., NK-T-B-antigen (NTB-A), are self-ligands. We determined the structure of the complex between the N-terminal domains of mouse 2B4 and CD48, as well as the structures of unbound 2B4 and CD48. The complex displayed an association mode related to, yet distinct from, that of the NTB-A dimer. Binding was accompanied by the rigidification of flexible 2B4 regions containing most of the polymorphic residues across different species and receptor isoforms. We propose a model for 2B4-CD48 interactions that permits the intermixing of SLAM receptors with major histocompatibility complex-specific receptors in the NK cell immune synapse. This analysis revealed the basis for heterophilic recognition within the SLAM family.
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===Structure of NK cell receptor ligand CD48===
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Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family.,Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:17950006<ref>PMID:17950006</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17950006}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2ptv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17950006 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17950006}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2PTV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PTV OCA].
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==Reference==
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Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family., Velikovsky CA, Deng L, Chlewicki LK, Fernandez MM, Kumar V, Mariuzza RA, Immunity. 2007 Oct;27(4):572-84. Epub 2007 Oct 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17950006 17950006]
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[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Single protein]]
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[[Category: Deng L]]
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[[Category: Deng, L.]]
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[[Category: Mariuzza RA]]
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[[Category: Mariuzza, R A.]]
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[[Category: Velikovsky CA]]
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[[Category: Velikovsky, C A.]]
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[[Category: Cd48]]
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[[Category: Immune system]]
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[[Category: Nk cell receptor]]
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[[Category: X-ray]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:14:28 2008''
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Current revision

Structure of NK cell receptor ligand CD48

PDB ID 2ptv

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