1pjw

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{{Seed}}
 
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[[Image:1pjw.png|left|200px]]
 
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==Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein==
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The line below this paragraph, containing "STRUCTURE_1pjw", creates the "Structure Box" on the page.
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<StructureSection load='1pjw' size='340' side='right'caption='[[1pjw]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Japanese_encephalitis_virus Japanese encephalitis virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PJW FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 15 models</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pjw OCA], [https://pdbe.org/1pjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pjw RCSB], [https://www.ebi.ac.uk/pdbsum/1pjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pjw ProSAT]</span></td></tr>
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{{STRUCTURE_1pjw| PDB=1pjw | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9J0X3_9FLAV Q9J0X3_9FLAV]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The flavivirus envelope protein is the dominant antigen in eliciting neutralizing antibodies and plays an important role in inducing immunologic responses in the infected host. We have determined the solution structure of the major antigenic domain (domain III) of the Japanese encephalitis virus (JEV) envelope protein. The JEV domain III forms a beta-barrel type structure composed of six antiparallel beta-strands resembling the immunoglobulin constant domain. We have also identified epitopes of the JEV domain III to its neutralizing antibody by chemical shift perturbation measurements. Site-directed mutagenesis experiments are performed to confirm the NMR results. Our study provides a structural basis for understanding the mechanism of immunologic protection and for rational design of vaccines effective against flaviviruses.
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===Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein===
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Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein.,Wu KP, Wu CW, Tsao YP, Kuo TW, Lou YC, Lin CW, Wu SC, Cheng JW J Biol Chem. 2003 Nov 14;278(46):46007-13. Epub 2003 Sep 2. PMID:12952958<ref>PMID:12952958</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1pjw" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 12952958 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_12952958}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1PJW is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Japanese_encephalitis_virus Japanese encephalitis virus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PJW OCA].
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==Reference==
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Structural basis of a flavivirus recognized by its neutralizing antibody: solution structure of the domain III of the Japanese encephalitis virus envelope protein., Wu KP, Wu CW, Tsao YP, Kuo TW, Lou YC, Lin CW, Wu SC, Cheng JW, J Biol Chem. 2003 Nov 14;278(46):46007-13. Epub 2003 Sep 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12952958 12952958]
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[[Category: Japanese encephalitis virus]]
[[Category: Japanese encephalitis virus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Lin, C W.]]
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[[Category: Lin CW]]
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[[Category: Lou, Y C.]]
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[[Category: Lou YC]]
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[[Category: Tsao, Y P.]]
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[[Category: Tsao YP]]
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[[Category: Wu, C W.]]
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[[Category: Wu CW]]
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[[Category: Wu, K P.]]
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[[Category: Wu KP]]
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[[Category: E protein]]
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[[Category: Epitope mapping]]
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[[Category: Flavivirus]]
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[[Category: Jev]]
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[[Category: Nmr]]
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[[Category: Structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:21:36 2008''
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Current revision

Solution Structure of the Domain III of the Japan Encephalitis Virus Envelope Protein

PDB ID 1pjw

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