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1jzn

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(New page: 200px<br /><applet load="1jzn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1jzn, resolution 2.20&Aring;" /> '''crystal structure of...)
Current revision (07:56, 3 April 2024) (edit) (undo)
 
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[[Image:1jzn.gif|left|200px]]<br /><applet load="1jzn" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1jzn, resolution 2.20&Aring;" />
 
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'''crystal structure of a galactose-specific C-type lectin'''<br />
 
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==Overview==
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==crystal structure of a galactose-specific C-type lectin==
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Rattlesnake venom lectin (RSL) from the western diamondback rattlesnake, (Crotalus atrox) is an oligomeric galactose-specific C-type lectin. The, X-ray crystal structure of RSL, in complex with lactose and, thiodigalactoside, at 2.2 and 2.3 A resolution, respectively, reveals a, decameric protein composed of two 5-fold symmetric pentamers arranged in a, staggered, back-to-back orientation. Each monomer corresponds to a single, canonical C-type lectin carbohydrate recognition domain devoid of, accessory domains and is disulfide-bonded to a monomer in the other, pentamer. The structure is the first example of that of a carbohydrate, complex of a vertebrate galactose-specific C-type lectin. The 10, carbohydrate-binding sites, located on the rim of the decamer, suggest a, role for multivalent interactions and a mechanism for RSL's ability to, promote receptor cross-linking and cell aggregation.
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<StructureSection load='1jzn' size='340' side='right'caption='[[1jzn]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1jzn]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZN FirstGlance]. <br>
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1JZN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Crotalus_atrox Crotalus atrox] with CA, NA and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1JZN OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PRD_900004:beta-lactose'>PRD_900004</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzn OCA], [https://pdbe.org/1jzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzn RCSB], [https://www.ebi.ac.uk/pdbsum/1jzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzn ProSAT]</span></td></tr>
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X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure., Walker JR, Nagar B, Young NM, Hirama T, Rini JM, Biochemistry. 2004 Apr 6;43(13):3783-92. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15049685 15049685]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LECG_CROAT LECG_CROAT] Galactose-binding protein which recognizes specific carbohydrate structures and agglutinates a variety of animal cells by binding to cell-surface glycoproteins and glycolipids. Calcium-dependent lectin. Shows high hemagglutinating activity (MHC is 10 ng/ml) (PubMed:1989986).<ref>PMID:1989986</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jz/1jzn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1jzn ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Crotalus atrox]]
[[Category: Crotalus atrox]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Hirama, T.]]
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[[Category: Hirama T]]
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[[Category: Nagar, B.]]
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[[Category: Nagar B]]
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[[Category: Rini, J.M.]]
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[[Category: Rini JM]]
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[[Category: Walker, J.R.]]
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[[Category: Walker JR]]
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[[Category: Young, N.M.]]
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[[Category: Young NM]]
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[[Category: CA]]
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[[Category: CL]]
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[[Category: NA]]
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[[Category: c-type lectin]]
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[[Category: protein-disaccharide complex]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:43:26 2007''
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Current revision

crystal structure of a galactose-specific C-type lectin

PDB ID 1jzn

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