1nnl

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{{Seed}}
 
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[[Image:1nnl.png|left|200px]]
 
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==Crystal structure of Human Phosphoserine Phosphatase==
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The line below this paragraph, containing "STRUCTURE_1nnl", creates the "Structure Box" on the page.
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<StructureSection load='1nnl' size='340' side='right'caption='[[1nnl]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1nnl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NNL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.53&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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{{STRUCTURE_1nnl| PDB=1nnl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnl OCA], [https://pdbe.org/1nnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nnl RCSB], [https://www.ebi.ac.uk/pdbsum/1nnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nnl ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:[https://omim.org/entry/614023 614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome.<ref>PMID:14673469</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/SERB_HUMAN SERB_HUMAN] Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.<ref>PMID:12777757</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nn/1nnl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1nnl ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of Human Phosphoserine Phosphatase===
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==See Also==
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*[[Phosphoserine phosphatase|Phosphoserine phosphatase]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 12777757 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_12777757}}
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==About this Structure==
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1NNL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NNL OCA].
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==Reference==
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High-resolution structure of human phosphoserine phosphatase in open conformation., Peeraer Y, Rabijns A, Verboven C, Collet JF, Van Schaftingen E, De Ranter C, Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):971-7. Epub 2003, May 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12777757 12777757]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphoserine phosphatase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Collet JF]]
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[[Category: Collet, J F.]]
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[[Category: De Ranter C]]
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[[Category: Peeraer, Y.]]
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[[Category: Peeraer Y]]
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[[Category: Rabijns, A.]]
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[[Category: Rabijns A]]
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[[Category: Ranter, C De.]]
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[[Category: Van Schaftingen E]]
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[[Category: Schaftingen, E Van.]]
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[[Category: Verboven C]]
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[[Category: Verboven, C.]]
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[[Category: Hpsp]]
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[[Category: Phospho-aspartyl]]
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[[Category: Phosphoserine phosphatase]]
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[[Category: Psp]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:49:57 2008''
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Current revision

Crystal structure of Human Phosphoserine Phosphatase

PDB ID 1nnl

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