1xni

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{{Seed}}
 
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[[Image:1xni.png|left|200px]]
 
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==Tandem Tudor Domain of 53BP1==
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The line below this paragraph, containing "STRUCTURE_1xni", creates the "Structure Box" on the page.
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<StructureSection load='1xni' size='340' side='right'caption='[[1xni]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xni]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XNI FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xni FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xni OCA], [https://pdbe.org/1xni PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xni RCSB], [https://www.ebi.ac.uk/pdbsum/1xni PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xni ProSAT]</span></td></tr>
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{{STRUCTURE_1xni| PDB=1xni | SCENE= }}
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</table>
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== Disease ==
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===Tandem Tudor Domain of 53BP1===
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein.
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== Function ==
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[https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref>
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_15525939}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 15525939 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_15525939}}
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==About this Structure==
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1XNI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XNI OCA].
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==Reference==
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Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks., Huyen Y, Zgheib O, Ditullio RA Jr, Gorgoulis VG, Zacharatos P, Petty TJ, Sheston EA, Mellert HS, Stavridi ES, Halazonetis TD, Nature. 2004 Nov 18;432(7015):406-11. Epub 2004 Nov 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15525939 15525939]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Gorgoulis, V G.]]
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[[Category: DiTullio Jr RA]]
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[[Category: Halazonetis, T D.]]
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[[Category: Gorgoulis VG]]
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[[Category: Huyen, Y.]]
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[[Category: Halazonetis TD]]
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[[Category: Jr., R A.DiTullio.]]
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[[Category: Huyen Y]]
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[[Category: Mellert, H S.]]
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[[Category: Mellert HS]]
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[[Category: Petty, T J.]]
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[[Category: Petty TJ]]
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[[Category: Sheston, E A.]]
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[[Category: Sheston EA]]
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[[Category: Stavridi, E S.]]
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[[Category: Stavridi ES]]
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[[Category: Zacharatos, P.]]
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[[Category: Zacharatos P]]
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[[Category: Zgheib, O.]]
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[[Category: Zgheib O]]
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[[Category: Bent beta-sheet]]
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[[Category: Beta-barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:51:37 2008''
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Current revision

Tandem Tudor Domain of 53BP1

PDB ID 1xni

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