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1p45

From Proteopedia

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{{Seed}}
 
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[[Image:1p45.png|left|200px]]
 
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==Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data==
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The line below this paragraph, containing "STRUCTURE_1p45", creates the "Structure Box" on the page.
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<StructureSection load='1p45' size='340' side='right'caption='[[1p45]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1p45]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P45 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1P45 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=TCL:TRICLOSAN'>TCL</scene></td></tr>
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{{STRUCTURE_1p45| PDB=1p45 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1p45 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1p45 OCA], [https://pdbe.org/1p45 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1p45 RCSB], [https://www.ebi.ac.uk/pdbsum/1p45 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1p45 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/INHA_MYCTU INHA_MYCTU]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p4/1p45_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1p45 ConSurf].
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<div style="clear:both"></div>
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===Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data===
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==See Also==
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*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_12606558}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 12606558 is the PubMed ID number.
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-->
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{{ABSTRACT_PUBMED_12606558}}
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==About this Structure==
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1P45 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P45 OCA].
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==Reference==
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Targeting tuberculosis and malaria through inhibition of Enoyl reductase: compound activity and structural data., Kuo MR, Morbidoni HR, Alland D, Sneddon SF, Gourlie BB, Staveski MM, Leonard M, Gregory JS, Janjigian AD, Yee C, Musser JM, Kreiswirth B, Iwamoto H, Perozzo R, Jacobs WR Jr, Sacchettini JC, Fidock DA, J Biol Chem. 2003 Jun 6;278(23):20851-9. Epub 2003 Feb 26. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12606558 12606558]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Alland D]]
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[[Category: Alland, D.]]
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[[Category: Fidock DA]]
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[[Category: Fidock, D A.]]
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[[Category: Gourlie BB]]
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[[Category: Gourlie, B B.]]
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[[Category: Gregory JS]]
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[[Category: Gregory, J S.]]
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[[Category: Iwamoto H]]
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[[Category: Iwamoto, H.]]
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[[Category: Jacobs Jr WR]]
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[[Category: Janjigian, A D.]]
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[[Category: Janjigian AD]]
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[[Category: Jr., W R.Jacobs.]]
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[[Category: Kreiswirth BN]]
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[[Category: Kreiswirth, B N.]]
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[[Category: Kuo MR]]
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[[Category: Kuo, M R.]]
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[[Category: Leonard M]]
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[[Category: Leonard, M.]]
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[[Category: Morbidoni HR]]
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[[Category: Morbidoni, H R.]]
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[[Category: Musser JM]]
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[[Category: Musser, J M.]]
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[[Category: Perozzo R]]
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[[Category: Perozzo, R.]]
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[[Category: Sacchettini JC]]
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[[Category: Sacchettini, J C.]]
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[[Category: Sneddon SF]]
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[[Category: Sneddon, S F.]]
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[[Category: Staveski MM]]
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[[Category: Staveski, M M.]]
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[[Category: Yee C]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Yee, C.]]
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[[Category: Enoyl-acp reductase]]
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[[Category: Inha]]
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[[Category: Protein structure initiative]]
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[[Category: Psi]]
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[[Category: Rossmann fold]]
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[[Category: Short chain dehydrogenase reductase]]
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[[Category: Structural genomic]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Tbsgc]]
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[[Category: Triclosan]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:54:21 2008''
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Current revision

Targeting tuberculosis and malaria through inhibition of enoyl reductase: compound activity and structural data

PDB ID 1p45

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