2afm

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{{Seed}}
 
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[[Image:2afm.png|left|200px]]
 
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==Crystal structure of human glutaminyl cyclase at pH 6.5==
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The line below this paragraph, containing "STRUCTURE_2afm", creates the "Structure Box" on the page.
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<StructureSection load='2afm' size='340' side='right'caption='[[2afm]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2afm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AFM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2afm| PDB=2afm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2afm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2afm OCA], [https://pdbe.org/2afm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2afm RCSB], [https://www.ebi.ac.uk/pdbsum/2afm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2afm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/QPCT_HUMAN QPCT_HUMAN] Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.<ref>PMID:15063747</ref> <ref>PMID:18486145</ref> <ref>PMID:21288892</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/af/2afm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2afm ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of human glutaminyl cyclase at pH 6.5===
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==See Also==
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*[[Glutaminyl cyclase|Glutaminyl cyclase]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_16135565}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 16135565 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_16135565}}
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==About this Structure==
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2AFM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AFM OCA].
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==Reference==
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Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation., Huang KF, Liu YL, Cheng WJ, Ko TP, Wang AH, Proc Natl Acad Sci U S A. 2005 Sep 13;102(37):13117-22. Epub 2005 Aug 31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16135565 16135565]
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[[Category: Glutaminyl-peptide cyclotransferase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Cheng, W J.]]
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[[Category: Cheng WJ]]
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[[Category: Huang, K F.]]
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[[Category: Huang KF]]
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[[Category: Ko, T P.]]
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[[Category: Ko TP]]
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[[Category: Liu, Y L.]]
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[[Category: Liu YL]]
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[[Category: Wang, A H.J.]]
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[[Category: Wang AHJ]]
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[[Category: Alpha-beta protein]]
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[[Category: Metalloprotein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:57:26 2008''
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Current revision

Crystal structure of human glutaminyl cyclase at pH 6.5

PDB ID 2afm

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