1pvh

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{{Seed}}
 
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[[Image:1pvh.png|left|200px]]
 
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==Crystal structure of leukemia inhibitory factor in complex with gp130==
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The line below this paragraph, containing "STRUCTURE_1pvh", creates the "Structure Box" on the page.
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<StructureSection load='1pvh' size='340' side='right'caption='[[1pvh]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pvh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PVH FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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{{STRUCTURE_1pvh| PDB=1pvh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pvh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pvh OCA], [https://pdbe.org/1pvh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pvh RCSB], [https://www.ebi.ac.uk/pdbsum/1pvh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pvh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/LIF_HUMAN LIF_HUMAN] LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pv/1pvh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pvh ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Gp130 is a shared cell-surface signaling receptor for at least ten different hematopoietic cytokines, but the basis of its degenerate recognition properties is unknown. We have determined the crystal structure of human leukemia inhibitory factor (LIF) bound to the cytokine binding region (CHR) of gp130 at 2.5 A resolution. Strikingly, we find that the shared binding site on gp130 has an entirely rigid core, while the LIF binding interface diverges sharply in structure and chemistry from that of other gp130 ligands. Dissection of the LIF-gp130 interface, along with comparative studies of other gp130 cytokines, reveal that gp130 has evolved a "thermodynamic plasticity" that is relatively insensitive to ligand structure, to enable crossreactivity. These observations reveal a novel and alternative mechanism for degenerate recognition from that of structural plasticity.
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===Crystal structure of leukemia inhibitory factor in complex with gp130===
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Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130.,Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC Mol Cell. 2003 Sep;12(3):577-89. PMID:14527405<ref>PMID:14527405</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 1pvh" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_14527405}}, adds the Publication Abstract to the page
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*[[Interleukin receptor 3D structures|Interleukin receptor 3D structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 14527405 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_14527405}}
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__TOC__
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</StructureSection>
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==About this Structure==
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1PVH is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVH OCA].
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==Reference==
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Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130., Boulanger MJ, Bankovich AJ, Kortemme T, Baker D, Garcia KC, Mol Cell. 2003 Sep;12(3):577-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/14527405 14527405]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Baker, D.]]
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[[Category: Baker D]]
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[[Category: Bankovich, A J.]]
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[[Category: Bankovich AJ]]
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[[Category: Boulanger, M J.]]
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[[Category: Boulanger MJ]]
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[[Category: Garcia, K C.]]
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[[Category: Garcia KC]]
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[[Category: Kortemme, T.]]
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[[Category: Kortemme T]]
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[[Category: Beta sheet]]
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[[Category: Cytokine]]
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[[Category: Four helix bundle]]
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[[Category: Receptor]]
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[[Category: Signaling]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:10:01 2008''
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Current revision

Crystal structure of leukemia inhibitory factor in complex with gp130

PDB ID 1pvh

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