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1sxm

From Proteopedia

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{{Seed}}
 
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[[Image:1sxm.png|left|200px]]
 
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==SCORPION TOXIN (NOXIUSTOXIN) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL AND LOW AFFINITY FOR CALCIUM DEPENDENT POTASSIUM CHANNEL (NMR AT 20 DEGREES, PH3.5, 39 STRUCTURES)==
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The line below this paragraph, containing "STRUCTURE_1sxm", creates the "Structure Box" on the page.
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<StructureSection load='1sxm' size='340' side='right'caption='[[1sxm]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1sxm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Centruroides_noxius Centruroides noxius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SXM FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_1sxm| PDB=1sxm | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1sxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1sxm OCA], [https://pdbe.org/1sxm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1sxm RCSB], [https://www.ebi.ac.uk/pdbsum/1sxm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1sxm ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAX21_CENNO KAX21_CENNO] Blocks voltage-gated non-inactivating potassium channels and unblocks inactivating potassium channels blocked by alpha-dendrotoxin in synaptosomes. Also displaces the alpha-dendrotoxin homolog dendrotoxin I from its receptor on brain synaptic membranes.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sx/1sxm_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1sxm ConSurf].
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<div style="clear:both"></div>
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===SCORPION TOXIN (NOXIUSTOXIN) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL AND LOW AFFINITY FOR CALCIUM DEPENDENT POTASSIUM CHANNEL (NMR AT 20 DEGREES, PH3.5, 39 STRUCTURES)===
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==See Also==
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8527429}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8527429 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8527429}}
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==About this Structure==
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1SXM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Centruroides_noxius Centruroides noxius]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SXM OCA].
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==Reference==
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Determination of the three-dimensional solution structure of noxiustoxin: analysis of structural differences with related short-chain scorpion toxins., Dauplais M, Gilquin B, Possani LD, Gurrola-Briones G, Roumestand C, Menez A, Biochemistry. 1995 Dec 26;34(51):16563-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8527429 8527429]
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[[Category: Centruroides noxius]]
[[Category: Centruroides noxius]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Dauplais, M.]]
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[[Category: Dauplais M]]
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[[Category: Gilquin, B.]]
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[[Category: Gilquin B]]
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[[Category: Gurrola-Briones, G.]]
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[[Category: Gurrola-Briones G]]
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[[Category: Menez, A.]]
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[[Category: Menez A]]
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[[Category: Possani, L D.]]
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[[Category: Possani LD]]
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[[Category: Roumestand, C.]]
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[[Category: Roumestand C]]
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[[Category: Toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:13:09 2008''
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Current revision

SCORPION TOXIN (NOXIUSTOXIN) WITH HIGH AFFINITY FOR VOLTAGE DEPENDENT POTASSIUM CHANNEL AND LOW AFFINITY FOR CALCIUM DEPENDENT POTASSIUM CHANNEL (NMR AT 20 DEGREES, PH3.5, 39 STRUCTURES)

PDB ID 1sxm

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