1k6u
From Proteopedia
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(New page: 200px<br /><applet load="1k6u" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k6u, resolution 1.00Å" /> '''Crystal Structure of...) |
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- | [[Image:1k6u.jpg|left|200px]]<br /><applet load="1k6u" size="450" color="white" frame="true" align="right" spinBox="true" | ||
- | caption="1k6u, resolution 1.00Å" /> | ||
- | '''Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor'''<br /> | ||
- | == | + | ==Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor== |
- | The crystal structure of a cyclic form of a mutant of bovine pancreatic | + | <StructureSection load='1k6u' size='340' side='right'caption='[[1k6u]], [[Resolution|resolution]] 1.00Å' scene=''> |
+ | == Structural highlights == | ||
+ | <table><tr><td colspan='2'>[[1k6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K6U FirstGlance]. <br> | ||
+ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1Å</td></tr> | ||
+ | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
+ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k6u OCA], [https://pdbe.org/1k6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k6u RCSB], [https://www.ebi.ac.uk/pdbsum/1k6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k6u ProSAT]</span></td></tr> | ||
+ | </table> | ||
+ | == Function == | ||
+ | [https://www.uniprot.org/uniprot/BPT1_BOVIN BPT1_BOVIN] Inhibits trypsin, kallikrein, chymotrypsin, and plasmin. | ||
+ | == Evolutionary Conservation == | ||
+ | [[Image:Consurf_key_small.gif|200px|right]] | ||
+ | Check<jmol> | ||
+ | <jmolCheckbox> | ||
+ | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k6/1k6u_consurf.spt"</scriptWhenChecked> | ||
+ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
+ | <text>to colour the structure by Evolutionary Conservation</text> | ||
+ | </jmolCheckbox> | ||
+ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k6u ConSurf]. | ||
+ | <div style="clear:both"></div> | ||
+ | <div style="background-color:#fffaf0;"> | ||
+ | == Publication Abstract from PubMed == | ||
+ | The crystal structure of a cyclic form of a mutant of bovine pancreatic trypsin inhibitor has been solved at 1.0 A resolution. The protein was synthesized by native chemical ligation and its structure is almost indistinguishable from the previously described recombinant form of the same mutant; however, the new loop containing the former termini became much better ordered. | ||
- | + | Crystal structure of a cyclic form of bovine pancreatic trypsin inhibitor.,Botos I, Wu Z, Lu W, Wlodawer A FEBS Lett. 2001 Nov 30;509(1):90-4. PMID:11734212<ref>PMID:11734212</ref> | |
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- | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
- | + | </div> | |
- | + | <div class="pdbe-citations 1k6u" style="background-color:#fffaf0;"></div> | |
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- | + | ==See Also== | |
+ | *[[BPTI 3D structures|BPTI 3D structures]] | ||
+ | == References == | ||
+ | <references/> | ||
+ | __TOC__ | ||
+ | </StructureSection> | ||
+ | [[Category: Bos taurus]] | ||
+ | [[Category: Large Structures]] | ||
+ | [[Category: Botos I]] | ||
+ | [[Category: Lu W]] | ||
+ | [[Category: Wlodawer A]] | ||
+ | [[Category: Wu Z]] |
Current revision
Crystal Structure of Cyclic Bovine Pancreatic Trypsin Inhibitor
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Categories: Bos taurus | Large Structures | Botos I | Lu W | Wlodawer A | Wu Z