1uke

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{{Seed}}
 
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[[Image:1uke.png|left|200px]]
 
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==UMP/CMP KINASE FROM SLIME MOLD==
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The line below this paragraph, containing "STRUCTURE_1uke", creates the "Structure Box" on the page.
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<StructureSection load='1uke' size='340' side='right'caption='[[1uke]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1uke]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ukd 1ukd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UKE FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UP5:P1-(ADENOSINE-5-P5-(URIDINE-5)PENTAPHOSPHATE'>UP5</scene></td></tr>
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{{STRUCTURE_1uke| PDB=1uke | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1uke FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1uke OCA], [https://pdbe.org/1uke PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1uke RCSB], [https://www.ebi.ac.uk/pdbsum/1uke PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1uke ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KCY_DICDI KCY_DICDI] This UMP-CMP kinase uses preferentially ATP as phosphate donor and is specific for UMP and CMP.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/uk/1uke_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1uke ConSurf].
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<div style="clear:both"></div>
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===UMP/CMP KINASE FROM SLIME MOLD===
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==See Also==
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*[[UMP/CMP kinase|UMP/CMP kinase]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8703943}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 8703943 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8703943}}
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==About this Structure==
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1UKE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1ukd 1ukd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UKE OCA].
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==Reference==
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Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity., Scheffzek K, Kliche W, Wiesmuller L, Reinstein J, Biochemistry. 1996 Jul 30;35(30):9716-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8703943 8703943]
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[[Category: Cytidylate kinase]]
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[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kliche, W.]]
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[[Category: Kliche W]]
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[[Category: Reinstein, J.]]
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[[Category: Reinstein J]]
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[[Category: Scheffzek, K.]]
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[[Category: Scheffzek K]]
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[[Category: Wiesmueller, L.]]
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[[Category: Wiesmueller L]]
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[[Category: Bisubstrate inhibitor]]
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[[Category: Nmp kinase]]
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[[Category: Nucleotide monophosphate kinase]]
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[[Category: Nucleotide specificity]]
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[[Category: Phosphoryl transfer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:50:01 2008''
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Current revision

UMP/CMP KINASE FROM SLIME MOLD

PDB ID 1uke

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