1k8i

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(New page: 200px<br /><applet load="1k8i" size="450" color="white" frame="true" align="right" spinBox="true" caption="1k8i, resolution 3.10&Aring;" /> '''CRYSTAL STRUCTURE OF...)
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[[Image:1k8i.jpg|left|200px]]<br /><applet load="1k8i" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1k8i, resolution 3.10&Aring;" />
 
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'''CRYSTAL STRUCTURE OF MOUSE H2-DM'''<br />
 
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==Overview==
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==CRYSTAL STRUCTURE OF MOUSE H2-DM==
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H2-M (HLA-DM in humans) resides in an acidic endosomal compartment, where, it facilitates the loading of antigenic peptides into the peptide-binding, groove of class II MHC. The crystal structure of a soluble form of H2-M, has been solved to 3.1 A resolution, revealing a heterodimer with, structural similarities to the MHC family of proteins. In contrast to its, antigen-presenting cousins, the membrane distal alpha helices of H2-M pack, closely together, occluding most of the binding groove except for a single, large pocket near the center. The structure of H2-M has several unique, features that may play a role in its function as a molecular chaperone and, peptide exchange factor.
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<StructureSection load='1k8i' size='340' side='right'caption='[[1k8i]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[1k8i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K8I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K8I FirstGlance]. <br>
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1K8I is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1K8I OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k8i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k8i OCA], [https://pdbe.org/1k8i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k8i RCSB], [https://www.ebi.ac.uk/pdbsum/1k8i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k8i ProSAT]</span></td></tr>
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Crystal structure of mouse H2-M., Fremont DH, Crawford F, Marrack P, Hendrickson WA, Kappler J, Immunity. 1998 Sep;9(3):385-93. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9768758 9768758]
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DMA_MOUSE DMA_MOUSE] Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k8/1k8i_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k8i ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Crawford F]]
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[[Category: Crawford, F.]]
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[[Category: Fremont DH]]
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[[Category: Fremont, D.H.]]
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[[Category: Hendrickson W]]
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[[Category: Hendrickson, W.]]
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[[Category: Kappler J]]
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[[Category: Kappler, J.]]
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[[Category: Marrack P]]
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[[Category: Marrack, P.]]
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[[Category: NAG]]
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[[Category: mhc]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 18:57:15 2007''
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Current revision

CRYSTAL STRUCTURE OF MOUSE H2-DM

PDB ID 1k8i

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