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1msk

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{{Seed}}
 
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[[Image:1msk.png|left|200px]]
 
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<!--
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==METHIONINE SYNTHASE (ACTIVATION DOMAIN)==
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The line below this paragraph, containing "STRUCTURE_1msk", creates the "Structure Box" on the page.
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<StructureSection load='1msk' size='340' side='right'caption='[[1msk]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1msk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1MSK FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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{{STRUCTURE_1msk| PDB=1msk | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1msk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1msk OCA], [https://pdbe.org/1msk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1msk RCSB], [https://www.ebi.ac.uk/pdbsum/1msk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1msk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/METH_ECOLI METH_ECOLI] Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ms/1msk_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1msk ConSurf].
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<div style="clear:both"></div>
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===METHIONINE SYNTHASE (ACTIVATION DOMAIN)===
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==See Also==
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*[[Methionine synthase 3D structures|Methionine synthase 3D structures]]
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__TOC__
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<!--
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_8939751}}, adds the Publication Abstract to the page
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[[Category: Escherichia coli K-12]]
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(as it appears on PubMed at http://www.pubmed.gov), where 8939751 is the PubMed ID number.
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[[Category: Large Structures]]
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[[Category: Dixon MM]]
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{{ABSTRACT_PUBMED_8939751}}
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[[Category: Huang S]]
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[[Category: Ludwig ML]]
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==About this Structure==
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[[Category: Matthews RG]]
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1MSK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MSK OCA].
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==Reference==
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The structure of the C-terminal domain of methionine synthase: presenting S-adenosylmethionine for reductive methylation of B12., Dixon MM, Huang S, Matthews RG, Ludwig M, Structure. 1996 Nov 15;4(11):1263-75. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8939751 8939751]
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[[Category: Escherichia coli]]
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[[Category: Methionine synthase]]
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[[Category: Single protein]]
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[[Category: Dixon, M M.]]
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[[Category: Huang, S.]]
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[[Category: Ludwig, M L.]]
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[[Category: Matthews, R G.]]
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[[Category: Methionine biosynthesis]]
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[[Category: Methyltransferase]]
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[[Category: Transferase]]
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[[Category: Vitamin b12]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:58:16 2008''
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Current revision

METHIONINE SYNTHASE (ACTIVATION DOMAIN)

PDB ID 1msk

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