1xsp

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{{Seed}}
 
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[[Image:1xsp.png|left|200px]]
 
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==Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate==
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The line below this paragraph, containing "STRUCTURE_1xsp", creates the "Structure Box" on the page.
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<StructureSection load='1xsp' size='340' side='right'caption='[[1xsp]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1xsp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XSP FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PPV:PYROPHOSPHATE'>PPV</scene></td></tr>
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{{STRUCTURE_1xsp| PDB=1xsp | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xsp OCA], [https://pdbe.org/1xsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xsp RCSB], [https://www.ebi.ac.uk/pdbsum/1xsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xsp ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DPOLL_HUMAN DPOLL_HUMAN] Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.<ref>PMID:11457865</ref> <ref>PMID:15537631</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xs/1xsp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xsp ConSurf].
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<div style="clear:both"></div>
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===Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate===
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==See Also==
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*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_15608652}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 15608652 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_15608652}}
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==About this Structure==
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1XSP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XSP OCA].
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==Reference==
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A closed conformation for the Pol lambda catalytic cycle., Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC, Nat Struct Mol Biol. 2005 Jan;12(1):97-8. Epub 2004 Dec 19. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15608652 15608652]
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[[Category: DNA-directed DNA polymerase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bebenek, K.]]
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[[Category: Bebenek K]]
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[[Category: Garcia-Diaz, M.]]
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[[Category: Garcia-Diaz M]]
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[[Category: Krahn, J M.]]
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[[Category: Krahn JM]]
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[[Category: Kunkel, T A.]]
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[[Category: Kunkel TA]]
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[[Category: Pedersen, L C.]]
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[[Category: Pedersen LC]]
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[[Category: Dna polymerase lambda]]
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[[Category: Helix-hairpin-helix]]
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[[Category: Protein-dna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:04:48 2008''
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Current revision

Crystal Structure of human DNA polymerase lambda in complex with nicked DNA and pyrophosphate

PDB ID 1xsp

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