1old

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{{Seed}}
 
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[[Image:1old.png|left|200px]]
 
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==NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES==
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The line below this paragraph, containing "STRUCTURE_1old", creates the "Structure Box" on the page.
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<StructureSection load='1old' size='340' side='right'caption='[[1old]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1old]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OLD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AAR:ARGININEAMIDE'>AAR</scene></td></tr>
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{{STRUCTURE_1old| PDB=1old | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1old FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1old OCA], [https://pdbe.org/1old PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1old RCSB], [https://www.ebi.ac.uk/pdbsum/1old PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1old ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Here we present the first solution structure of a ligand-DNA aptamer complex. Our NMR-molecular dynamics structural studies of the interaction between argininamide and a DNA stem-loop complex establishes that the hairpin loop DNA binding site undergoes an adaptive conformational transition on complex formation. The tip of the DNA loop folds down towards the stem and sandwiches the bound argininamide between reversed Hoogsteen A.C and Watson-Crick G.C base pairs. The argininamide is encapsulated within the structured DNA loop and is stabilized by an intricate set of intermolecular hydrogen bonds and stacking interactions. The structure of the complex lays out the molecular principles defining both the architecture of the internal cavity and the recognition elements that could contribute to ligand discrimination.
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===NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES===
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Encapsulating an amino acid in a DNA fold.,Lin CH, Patel DJ Nat Struct Biol. 1996 Dec;3(12):1046-50. PMID:8946859<ref>PMID:8946859</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_8946859}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1old" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 8946859 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_8946859}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OLD OCA].
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[[Category: Lin CH]]
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[[Category: Patel DJ]]
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==Reference==
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Encapsulating an amino acid in a DNA fold., Lin CH, Patel DJ, Nat Struct Biol. 1996 Dec;3(12):1046-50. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8946859 8946859]
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[[Category: Lin, C H.]]
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[[Category: Patel, D J.]]
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[[Category: Deoxyribonucleic acid]]
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[[Category: Dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:12:26 2008''
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Current revision

NMR STRUCTURE OF 24-MER DEOXYRIBONUCLEIC ACID, 7 STRUCTURES

PDB ID 1old

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