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1pic

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{{Seed}}
 
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[[Image:1pic.png|left|200px]]
 
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==PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE==
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The line below this paragraph, containing "STRUCTURE_1pic", creates the "Structure Box" on the page.
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<StructureSection load='1pic' size='340' side='right'caption='[[1pic]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1pic]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PIC FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
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{{STRUCTURE_1pic| PDB=1pic | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pic FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pic OCA], [https://pdbe.org/1pic PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pic RCSB], [https://www.ebi.ac.uk/pdbsum/1pic PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pic ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P85A_HUMAN P85A_HUMAN] Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling.<ref>PMID:7518429</ref> <ref>PMID:17626883</ref> <ref>PMID:19805105</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pi/1pic_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pic ConSurf].
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<div style="clear:both"></div>
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===PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE===
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==See Also==
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 8670861 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_8670861}}
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==About this Structure==
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1PIC is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PIC OCA].
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==Reference==
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Structure of a specific peptide complex of the carboxy-terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3-kinase., Breeze AL, Kara BV, Barratt DG, Anderson M, Smith JC, Luke RW, Best JR, Cartlidge SA, EMBO J. 1996 Jul 15;15(14):3579-89. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8670861 8670861]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phosphatidylinositol 3-kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Anderson M]]
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[[Category: Anderson, M.]]
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[[Category: Barratt DG]]
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[[Category: Barratt, D G.]]
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[[Category: Best JR]]
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[[Category: Best, J R.]]
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[[Category: Breeze AL]]
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[[Category: Breeze, A L.]]
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[[Category: Cartlidge SA]]
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[[Category: Cartlidge, S A.]]
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[[Category: Kara BV]]
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[[Category: Kara, B V.]]
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[[Category: Luke RW]]
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[[Category: Luke, R W.]]
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[[Category: Smith JC]]
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[[Category: Smith, J C.]]
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[[Category: Phosphoinositide 3-kinase]]
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[[Category: Phosphotransferase]]
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[[Category: Sh2 domain]]
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[[Category: Signal transduction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:22:27 2008''
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Current revision

PHOSPHATIDYLINOSITOL 3-KINASE, P85-ALPHA SUBUNIT: C-TERMINAL SH2 DOMAIN COMPLEXED WITH A TYR751 PHOSPHOPEPTIDE FROM THE PDGF RECEPTOR, NMR, MINIMIZED MEAN STRUCTURE

PDB ID 1pic

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