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1y1p

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{{Seed}}
 
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[[Image:1y1p.png|left|200px]]
 
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==X-ray structure of aldehyde reductase with NADPH==
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The line below this paragraph, containing "STRUCTURE_1y1p", creates the "Structure Box" on the page.
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<StructureSection load='1y1p' size='340' side='right'caption='[[1y1p]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1y1p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sporidiobolus_salmonicolor Sporidiobolus salmonicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1Y1P FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=NMN:BETA-NICOTINAMIDE+RIBOSE+MONOPHOSPHATE'>NMN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_1y1p| PDB=1y1p | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1y1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1y1p OCA], [https://pdbe.org/1y1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1y1p RCSB], [https://www.ebi.ac.uk/pdbsum/1y1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1y1p ProSAT]</span></td></tr>
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</table>
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===X-ray structure of aldehyde reductase with NADPH===
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== Function ==
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[https://www.uniprot.org/uniprot/ALD2_SPOSA ALD2_SPOSA] Catalyzes the asymmetric reduction of o-substituted aliphatic and aromatic aldehydes and ketones to an S-enantiomer. Reduces ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate.<ref>PMID:10583966</ref> [REFERENCE:2]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16095619}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16095619 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/y1/1y1p_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16095619}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1Y1P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Sporidiobolus_salmonicolor Sporidiobolus salmonicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Y1P OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1y1p ConSurf].
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<div style="clear:both"></div>
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==Reference==
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== References ==
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X-ray structures of NADPH-dependent carbonyl reductase from Sporobolomyces salmonicolor provide insights into stereoselective reductions of carbonyl compounds., Kamitori S, Iguchi A, Ohtaki A, Yamada M, Kita K, J Mol Biol. 2005 Sep 23;352(3):551-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16095619 16095619]
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<references/>
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[[Category: Single protein]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Sporidiobolus salmonicolor]]
[[Category: Sporidiobolus salmonicolor]]
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[[Category: Kamitori, S.]]
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[[Category: Kamitori S]]
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[[Category: Kita, K.]]
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[[Category: Kita K]]
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[[Category: Rossmann fold]]
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[[Category: Short chain dehydrogenase reductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:30:41 2008''
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Current revision

X-ray structure of aldehyde reductase with NADPH

PDB ID 1y1p

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