1xa6

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:48, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:1xa6.png|left|200px]]
 
-
<!--
+
==Crystal Structure of the Human Beta2-Chimaerin==
-
The line below this paragraph, containing "STRUCTURE_1xa6", creates the "Structure Box" on the page.
+
<StructureSection load='1xa6' size='340' side='right'caption='[[1xa6]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1xa6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XA6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XA6 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_1xa6| PDB=1xa6 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xa6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xa6 OCA], [https://pdbe.org/1xa6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xa6 RCSB], [https://www.ebi.ac.uk/pdbsum/1xa6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xa6 ProSAT]</span></td></tr>
-
 
+
</table>
-
===Crystal Structure of the Human Beta2-Chimaerin===
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/CHIO_HUMAN CHIO_HUMAN] GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors.
-
 
+
== Evolutionary Conservation ==
-
<!--
+
[[Image:Consurf_key_small.gif|200px|right]]
-
The line below this paragraph, {{ABSTRACT_PUBMED_15507211}}, adds the Publication Abstract to the page
+
Check<jmol>
-
(as it appears on PubMed at http://www.pubmed.gov), where 15507211 is the PubMed ID number.
+
<jmolCheckbox>
-
-->
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/1xa6_consurf.spt"</scriptWhenChecked>
-
{{ABSTRACT_PUBMED_15507211}}
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
 
+
<text>to colour the structure by Evolutionary Conservation</text>
-
==About this Structure==
+
</jmolCheckbox>
-
1XA6 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XA6 OCA].
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xa6 ConSurf].
-
 
+
<div style="clear:both"></div>
-
==Reference==
+
__TOC__
-
Structural mechanism for lipid activation of the Rac-specific GAP, beta2-chimaerin., Canagarajah B, Leskow FC, Ho JY, Mischak H, Saidi LF, Kazanietz MG, Hurley JH, Cell. 2004 Oct 29;119(3):407-18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15507211 15507211]
+
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Canagarajah, B.]]
+
[[Category: Canagarajah B]]
-
[[Category: Ho, J Y.]]
+
[[Category: Ho JY]]
-
[[Category: Hurley, J H.]]
+
[[Category: Hurley JH]]
-
[[Category: Kazanietz, M G.]]
+
[[Category: Kazanietz MG]]
-
[[Category: Leskow, F C.]]
+
[[Category: Leskow FC]]
-
[[Category: Mischak, H.]]
+
[[Category: Mischak H]]
-
[[Category: Saidi, L F.]]
+
[[Category: Saidi LF]]
-
[[Category: Beta2-chimaerin]]
+
-
[[Category: C1]]
+
-
[[Category: Racgap]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:30:51 2008''
+

Current revision

Crystal Structure of the Human Beta2-Chimaerin

PDB ID 1xa6

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1xa6"
Personal tools