1tif

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{{Seed}}
 
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[[Image:1tif.png|left|200px]]
 
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<!--
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==TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN==
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The line below this paragraph, containing "STRUCTURE_1tif", creates the "Structure Box" on the page.
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<StructureSection load='1tif' size='340' side='right'caption='[[1tif]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1tif]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TIF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PBM:TRIMETHYL+LEAD+ION'>PBM</scene></td></tr>
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{{STRUCTURE_1tif| PDB=1tif | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tif FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tif OCA], [https://pdbe.org/1tif PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tif RCSB], [https://www.ebi.ac.uk/pdbsum/1tif PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tif ProSAT]</span></td></tr>
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</table>
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===TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN===
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== Function ==
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[https://www.uniprot.org/uniprot/IF3_GEOSE IF3_GEOSE] IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_7664745}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 7664745 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ti/1tif_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_7664745}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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1TIF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TIF OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tif ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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X-ray crystallography shows that translational initiation factor IF3 consists of two compact alpha/beta domains linked by an alpha-helix., Biou V, Shu F, Ramakrishnan V, EMBO J. 1995 Aug 15;14(16):4056-64. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7664745 7664745]
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</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Biou, V.]]
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[[Category: Biou V]]
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[[Category: Ramakrishnan, V.]]
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[[Category: Ramakrishnan V]]
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[[Category: Shu, F.]]
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[[Category: Shu F]]
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[[Category: If3 n-terminal domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:51:22 2008''
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Current revision

TRANSLATION INITIATION FACTOR 3 N-TERMINAL DOMAIN

PDB ID 1tif

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