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2a2j

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==Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis==
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[[Image:2a2j.png|left|200px]]
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<StructureSection load='2a2j' size='340' side='right' caption='[[2a2j]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2a2j]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2A2J FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pyridoxal_5'-phosphate_synthase Pyridoxal 5'-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.4.3.5 1.4.3.5] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a2j OCA], [http://pdbe.org/2a2j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2a2j RCSB], [http://www.ebi.ac.uk/pdbsum/2a2j PDBsum], [http://www.topsan.org/Proteins/TBSGC/2a2j TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/PDXH_MYCTU PDXH_MYCTU]] Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity).[HAMAP-Rule:MF_01629]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a2/2a2j_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a2j ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The three-dimensional structure of Rv2607, a putative pyridoxine 5'-phosphate oxidase (PNPOx) from Mycobacterium tuberculosis, has been determined by X-ray crystallography to 2.5 A resolution. Rv2607 has a core domain similar to known PNPOx structures with a flavin mononucleotide (FMN) cofactor. Electron density for two FMN at the dimer interface is weak despite the bright yellow color of the protein solution and crystal. The shape and size of the putative binding pocket is markedly different from that of members of the PNPOx family, which may indicate some significant changes in the FMN binding mode of this protein relative to members of the family.
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Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis.,Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC Proteins. 2006 Mar 15;62(3):563-9. PMID:16374842<ref>PMID:16374842</ref>
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The line below this paragraph, containing "STRUCTURE_2a2j", creates the "Structure Box" on the page.
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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or leave the SCENE parameter empty for the default display.
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-->
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{{STRUCTURE_2a2j| PDB=2a2j | SCENE= }}
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===Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis===
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2a2j" style="background-color:#fffaf0;"></div>
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<!--
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_16374842}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 16374842 is the PubMed ID number.
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__TOC__
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-->
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</StructureSection>
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{{ABSTRACT_PUBMED_16374842}}
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==About this Structure==
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2A2J is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A2J OCA].
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==Reference==
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Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis., Pedelacq JD, Rho BS, Kim CY, Waldo GS, Lekin TP, Segelke BW, Rupp B, Hung LW, Kim SI, Terwilliger TC, Proteins. 2006 Mar 15;62(3):563-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16374842 16374842]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Pyridoxal 5'-phosphate synthase]]
[[Category: Pyridoxal 5'-phosphate synthase]]
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[[Category: Single protein]]
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[[Category: Hung, L W]]
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[[Category: Hung, L W.]]
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[[Category: Kim, C Y]]
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[[Category: Kim, C Y.]]
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[[Category: Kim, S I]]
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[[Category: Kim, S I.]]
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[[Category: Lekin, T P]]
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[[Category: Lekin, T P.]]
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[[Category: Pedelacq, J D]]
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[[Category: Pedelacq, J D.]]
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[[Category: Rho, B S]]
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[[Category: Rho, B S.]]
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[[Category: Rupp, B]]
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[[Category: Rupp, B.]]
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[[Category: Segelke, B W]]
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[[Category: Segelke, B W.]]
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[[Category: Terwilliger, T C]]
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[[Category: Terwilliger, T C.]]
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[[Category: Waldo, G S]]
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[[Category: Waldo, G S.]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project]]
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[[Category: XMTB, Mycobacterium Tuberculosis Structural Proteomics Project.]]
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[[Category: Beta barrel]]
[[Category: Beta barrel]]
[[Category: Mycobacterium tuberculosis structural proteomics project]]
[[Category: Mycobacterium tuberculosis structural proteomics project]]
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[[Category: Oxidoreductase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
[[Category: Xmtb]]
[[Category: Xmtb]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:12:31 2008''
 

Current revision

Crystal structure of a putative pyridoxine 5'-phosphate oxidase (Rv2607) from Mycobacterium tuberculosis

2a2j, resolution 2.50Å

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