2hje

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{{Seed}}
 
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[[Image:2hje.png|left|200px]]
 
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==Crystal structure of Vibrio harveyi LuxQ periplasmic domain==
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The line below this paragraph, containing "STRUCTURE_2hje", creates the "Structure Box" on the page.
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<StructureSection load='2hje' size='340' side='right'caption='[[2hje]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hje]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HJE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HJE FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
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{{STRUCTURE_2hje| PDB=2hje | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hje OCA], [https://pdbe.org/2hje PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hje RCSB], [https://www.ebi.ac.uk/pdbsum/2hje PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hje ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Vibrio harveyi LuxQ periplasmic domain===
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== Function ==
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[https://www.uniprot.org/uniprot/LUXQ_VIBHA LUXQ_VIBHA] At low cell density, in absence of AI-2 (autoinducer 2), LuxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to LuxU, and ultimately to LuxO. At high cell density, in the presence of AI-2, the kinase activity is inactivated, and the response regulator domain has a phosphatase activity.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hj/2hje_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16990134}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2HJE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Vibrio_harveyi Vibrio harveyi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HJE OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hje ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing., Neiditch MB, Federle MJ, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM, Cell. 2006 Sep 22;126(6):1095-108. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16990134 16990134]
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</StructureSection>
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[[Category: Histidine kinase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Vibrio harveyi]]
[[Category: Vibrio harveyi]]
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[[Category: Hughson, F M.]]
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[[Category: Hughson FM]]
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[[Category: Kelly, R C.]]
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[[Category: Kelly RC]]
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[[Category: Neiditch, M B.]]
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[[Category: Neiditch MB]]
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[[Category: Histidine sensor kinase]]
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[[Category: Quorum sensing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:18:26 2008''
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Current revision

Crystal structure of Vibrio harveyi LuxQ periplasmic domain

PDB ID 2hje

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