2oiv

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{{Seed}}
 
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[[Image:2oiv.png|left|200px]]
 
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==Structural Analysis of Xanthomonas XopD Provides Insights Into Substrate Specificity of Ubiquitin-like Protein Proteases==
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The line below this paragraph, containing "STRUCTURE_2oiv", creates the "Structure Box" on the page.
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<StructureSection load='2oiv' size='340' side='right'caption='[[2oiv]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2oiv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Xanthomonas_euvesicatoria Xanthomonas euvesicatoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OIV FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
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{{STRUCTURE_2oiv| PDB=2oiv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2oiv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oiv OCA], [https://pdbe.org/2oiv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2oiv RCSB], [https://www.ebi.ac.uk/pdbsum/2oiv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2oiv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q3BYJ5_XANC5 Q3BYJ5_XANC5]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oi/2oiv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2oiv ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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XopD (Xanthomonas outer protein D), a type III secreted effector from Xanthomonas campestris pv. vesicatoria, is a desumoylating enzyme with strict specificity for its plant small ubiquitin-like modifier (SUMO) substrates. Based on SUMO sequence alignments and peptidase assays with various plant, yeast, and mammalian SUMOs, we identified residues in SUMO that contribute to XopD/SUMO recognition. Further predictions regarding the enzyme/substrate specificity were made by solving the XopD crystal structure. By incorporating structural information with sequence alignments and enzyme assays, we were able to elucidate determinants of the rigid SUMO specificity exhibited by the Xanthomonas virulence factor XopD.
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===Structural Analysis of Xanthomonas XopD Provides Insights Into Substrate Specificity of Ubiquitin-like Protein Proteases===
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Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases.,Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K J Biol Chem. 2007 Mar 2;282(9):6773-82. Epub 2007 Jan 3. PMID:17204475<ref>PMID:17204475</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_17204475}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 2oiv" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 17204475 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_17204475}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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2OIV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xanthomonas_euvesicatoria Xanthomonas euvesicatoria]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OIV OCA].
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==Reference==
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Structural analysis of Xanthomonas XopD provides insights into substrate specificity of ubiquitin-like protein proteases., Chosed R, Tomchick DR, Brautigam CA, Mukherjee S, Negi VS, Machius M, Orth K, J Biol Chem. 2007 Mar 2;282(9):6773-82. Epub 2007 Jan 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17204475 17204475]
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[[Category: Single protein]]
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[[Category: Xanthomonas euvesicatoria]]
[[Category: Xanthomonas euvesicatoria]]
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[[Category: Brautigam, C A.]]
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[[Category: Brautigam CA]]
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[[Category: Chosed, R.]]
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[[Category: Chosed R]]
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[[Category: Machius, M.]]
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[[Category: Machius M]]
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[[Category: Orth, K.]]
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[[Category: Orth K]]
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[[Category: Tomchick, D R.]]
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[[Category: Tomchick DR]]
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[[Category: Clan ce family 48 cysteine protease]]
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[[Category: Desumoylating enzyme]]
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[[Category: Isopeptidase]]
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[[Category: Peptidase]]
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[[Category: Secreted virulence factor]]
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[[Category: Type iii secreted effector]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:19:04 2008''
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Current revision

Structural Analysis of Xanthomonas XopD Provides Insights Into Substrate Specificity of Ubiquitin-like Protein Proteases

PDB ID 2oiv

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