2hb3

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{{Seed}}
 
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[[Image:2hb3.png|left|200px]]
 
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==Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579==
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The line below this paragraph, containing "STRUCTURE_2hb3", creates the "Structure Box" on the page.
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<StructureSection load='2hb3' size='340' side='right'caption='[[2hb3]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2hb3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HB3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GRL:(3AS,5R,6AR)-HEXAHYDRO-2H-CYCLOPENTA[B]FURAN-5-YL+(2S,3S)-3-HYDROXY-4-(4-(HYDROXYMETHYL)-N-ISOBUTYLPHENYLSULFONAMIDO)-1-PHENYLBUTAN-2-YLCARBAMATE'>GRL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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{{STRUCTURE_2hb3| PDB=2hb3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hb3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hb3 OCA], [https://pdbe.org/2hb3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hb3 RCSB], [https://www.ebi.ac.uk/pdbsum/2hb3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hb3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q7SSI0_9HIV1 Q7SSI0_9HIV1]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hb/2hb3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hb3 ConSurf].
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<div style="clear:both"></div>
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===Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579===
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==See Also==
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*[[Immunodeficiency virus protease 3D structures|Immunodeficiency virus protease 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_16913714}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16913714 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16913714}}
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==About this Structure==
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2HB3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HB3 OCA].
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==Reference==
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Structure-based design of novel HIV-1 protease inhibitors to combat drug resistance., Ghosh AK, Sridhar PR, Leshchenko S, Hussain AK, Li J, Kovalevsky AY, Walters DE, Wedekind JE, Grum-Tokars V, Das D, Koh Y, Maeda K, Gatanaga H, Weber IT, Mitsuya H, J Med Chem. 2006 Aug 24;49(17):5252-61. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16913714 16913714]
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[[Category: Chymosin]]
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[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Kovalevsky, A Y.]]
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[[Category: Kovalevsky AY]]
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[[Category: Weber, I T.]]
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[[Category: Weber IT]]
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[[Category: Active-site cavity protease inhibitor catalytic aspartic acid]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:20:28 2008''
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Current revision

Wild-type HIV-1 Protease in complex with potent inhibitor GRL06579

PDB ID 2hb3

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